Abstract A21: Human breast-to-brain metastases display GABAergic properties in the neural niche The high frequency and poor prognosis of breast-to-brain metastasis (BBM) indicates the need for detailed studies of metastatic breast cancer cells, the br... J Neman,J Termini,CM Kowolik,... -...
Despite recent advances in the treatment of primary breast tumors, the prognosis for breast cancer patients with brain metastases remains poor overall—although the prognosis of such patients is actually heterogeneous, with some individuals achieving a better survival outcome than others [8]. Several pr...
"The prognosis for individuals with brain metastases from breast cancer is extremely unfavorable, and the management of breast cancer metastases in the brain remains a formidable challenge," said senior author Jennifer Carew, Ph.D. "We were able to disrupt breast cancer cells' ability to form bra...
However, there is limited insight into the natural progression, therapeutics, and patient outcomes for prostate cancer once metastasized to the brain. This is a retrospective study of 461 patients with metastatic prostate cancer to the brain with a primary outcome of median overall survival (OS). ...
The presence of metastasized cancer in the lymph nodes is may mean the cancer is growing quickly and/or is more likely to spread to other sites. The presence of cancer in lymph nodes often affects prognosis and treatment decisions. Many diagnostic tests look at the lymph nodes as an ...
Furthermore, studies from patient-derived-xenograft models suggested that breast cancer cells that metastasized to the brain enhanced glucose oxidation, mitochondrial respiration, pentose-phosphate-pathway (PPP) and increased glutathione synthesis, when compared to the cells derived from the originating ...
The presence of metastasized cancer in the lymph nodes is may mean the cancer is growing quickly and/or is more likely to spread to other sites. The presence of cancer in lymph nodes often affects prognosis and treatment decisions. Many diagnostic tests look at the lymph nodes as an ...
When the cancer has already metastasized, the symptoms will likely appear in various parts of the body. Once the cancer grows enough to push blood vessels, nerves, and nearby organs, it cause the emergence of various symptoms . Extreme fatigue, weight loss and fever are the most common ...
Article Open access 20 December 2021 Metastasis-associated fibroblasts promote angiogenesis in metastasized pancreatic cancer via the CXCL8 and the CCL2 axes Article Open access 25 March 2020 Introduction More than four decades after their first approval, platinum drugs still stand among the most wi...
teasing the possibility of a new breakthrough. Cure for cancer post-metastases still seems tantalisingly out of reach. Once metastasized, cancer-related death is extremely difficult, if not impossible, to be reversed. Here we present cancer pre-metastasis chemoprevention strategy that can prevent ci...