Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant activity of various cell cycle proteins. Therefore, cell cycle regulators are considered attractive targets in cancer therapy. Intriguingly, animal models demonstrate that some of these proteins are not essential for pr...
HPBC, a subtype of breast cancer, is characterized by the overexpression of HER2 protein2, shows drug resistance and highly aggressive biology, and is associated with poor survival3,4,5. Published data show that HPBC accounts for one-fourth to one-fifth of breast cancers6. According to NCCN...
If disease flare occurs, restart EGFR TKI." NSCL-A 1 of 4 · Pathologic evaluation > Bullet 1 modified: The purpose of pathologic evaluation is to precisely classify the histologic type of lung cancer and to determine all staging parameters as recommended by the AJCC, including tumor size, ...
Department. The project of "Experimental Infection of Human Hepatitis B Virus (HBV) in Tree Shrews" won the second prize of The National Scientific and Technological Progress Award, which is the highest level of scientific and technological award won by Guangxi’s medical and health system so ...
CAF heterogeneity in pan-cancer.aUMAP plots showing the integration of fibroblasts across six different cancer types by Harmony.bDifferential expression analysis showing the upregulated genes for each fibroblast subtype. An adjustedpvalue < 0.05 is indicated in red, while an adjustedpvalue ≥...
Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes, transcription factors, signaling pathways and receptors; furthermore, collage
The co-infiltration of B cells and CD8 + T cells is observed in MIBC, wherein characterized by a high proportion of PD-1 + TCF1 + progenitor T cells, naïve T cells and activated B cells [52]. We utilized immunofluorescence and IHC techniques to gain deeper insights into...
Cancer is the second cause of death worldwide and is characterized by several hallmarks47; cell transformation, genome instability, hyperproliferation, immortalization, angiogenesis, epithelial-mesenchymal transition (EMT) and metastasis, which are all influenced in several ways by intracellular ROS48,49....
realized the first single cells MS experiment, while in 1998 Steven Oliver firstly introduced the concept of metabolomics. 2004 is the year of Next-generation sequencing (NGS), 2006 of the Seahorse real-time cell metabolic analyser, 2007 of the first prototype of Cytometry by Time-of-flight (...
Colorectal cancer (CRC) is one of the most common cancers worldwide characterized by disparities in age, gender, race and anatomic sites. The mechanism underlying pathogenesis, progression and disparities of C... Authors: Zhirong Liu, Christian R. Gomez, Ingrid Espinoza, Thuy Phuong T. Le, ...