Introduction The Cancer Genome Atlas (TCGA), available from the NCI Genomic Data Commons (GDC)1, provides RNA-seq and whole genomic sequencing (WGS) data for thousands of cases across dozens of cancer types. RNA-seq data is typically used to measure the expression of human genes, and there...
The hospital owns four national platforms: oncology has been designated as the national project aimed at enhancing the diagnosis and treatment capabilities for challenging diseases; it has also been identified as a national key cultivation discipline; recognized as a national clinical key specialty; and...
Introduction Prostate cancer (PCa) is one of the most frequent cancers in males and is most prevalent in males 65 and older, with over 1.4 million new cases and 375,000 deaths expected globally in 20201,2,3,4,5,6,7. In recent years, with the continuous economic and social development ...
Introduction Accurate staging of lymph node involvement is a critical aspect of the initial management of nonmetastatic non-small cell lung cancer (NSCLC). We sought to determine whether the current N descriptors should be maintained or revised for the next edition of the international lung cancer ...
“Screening patients for heterozygotous p53 mutations using a functional assay in yeast” Nature Genet. 1993; 5:124–129. Article CAS Google Scholar Islas AL, Vos J-M and Hanawalt PC “Differential introduction and repair of psoralen photoadducts to DNA in specific human genes”. Cancer ...
1. Introduction Breast cancer is the most common form of cancer among women [1,2]. In 2018, breast cancer mortality trends decreased by 41% due to various factors, including early diagnosis, advancements in treatment, lifestyle changes, improved nutrition, and research [3,4]. This increased ...
Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis showed remarkable improvements in overall response and patient survival, which changed the treatment landscape for multiple cancer types. However, the majority of patients receiving ICIs are either non-responders or eventually develop sec...
Summary of Recommendation Introduction Lung cancer is the second most common cancer and the leading cause of cancer death in the US. In 2020, an estimated 228 820 persons were diagnosed with lung cancer, and 135 720 persons died of the disease.1 The most important risk factor for lung ...
(D recommendation) The USPSTF recommends against screening for cervical cancer in women who have had a hysterectomy with removal of the cervix and do not have a history of a high-grade precancerous lesion or cervical cancer. (D recommendation) Introduction The US Preventive Services Task Force ...
Introduction Bladder cancer ranks as the tenth most frequently diagnosed cancer globally [1]. Muscle-invasive bladder cancer (MIBC) involves invasion of the detrusor muscle layer or concurrent metastasis and is a highly aggressive disease with a poor prognosis [2,3,4]. The tumor microenvironment (...