These cancers, or malignanttumors, are sometimes referred to as colorectal cancer, reflecting the fact that the rectum, the end portion of the colon, can also be affected. Anatomic differences in the rectum as compared to the rest of the colon require that these areas be separately recognized ...
A 0.5 cm snip of the colon containing a stool pellet was embedded in TissueTek and snap-frozen in liquid nitrogen. Another 0.5 cm snip was directly snap-frozen in liquid nitrogen. The rest of the colon was cut open longitudinally, macroscopic tumours were counted blindly by two ...
Immunotherapies play critical roles in cancer treatment. However, given that only a few patients respond to immune checkpoint blockades and other immunotherapeutic strategies, more novel technologies are needed to decipher the complicated interplay between tumor cells and the components of the tumor immune...
Ma's group117 utilized the azoreductase specifically secreted by colonic bacteria to cleave the azo bond in the DMF-loaded sPCEG-azo polymer micelles, which triggered the release of DMF at the colon, and thereby caused the depletion of GSH, the elevation of ROS levels, the activation of the...
Tibor Tot has given me an unusual opportunity via his request to summarize my work in computed tomography (CT), which indeed since 1977 has been directed toward eliminating the scourge of breast cancer via search and destroy of premetastasis tumors, inst
in theBioMed Central Gastroenterologyjournal discovered that luteolin is able to block the signal pathways (IGF and PI3K) which are necessary for the growth of cancer cells, specifically colorectal cancers. In developed nations, colon cancer is the second most frequent cause of cancer-related death....
Doxorubicin/Cyclophosphamide (AC) is one of the standard adjuvant anthracycline-containing regimens that is still in use for breast cancer treatment. Cancer cell resistance and AC-induced side effects make treatment suboptimal and worsen patients’ quality of life. This study aimed to improve trans-fe...
A CT brush consists of a “star” pattern of x-ray beams (rays) through a given point in the patient (Figures1,2and3). The point at which all beams in the brush intersect is called the “central point”. As the brush moves, both the central point and all of the star lines throug...
We discover that the chloride intracellular channel protein 3 (CLIC3) is an abundant component of the CAF secretome. Secreted CLIC3 promotes invasive behaviour of endothelial cells to drive angiogenesis and increases invasiveness of cancer cells both in vivo and in 3D cell culture models, and this...
as evidenced by the high mutation rate ofTP53in ovary cancer and colon cancer42. Unlike other cancers with specific mutations such asBRCA1/2in breast cancer andEGFRin lung cancer, ESCC lacks tumor-specific mutations. Notably, somatic mutations also occur in physiologically normal human esophageal ...