2024年10月10日,维尔康奈尔医学中心Lorenzo Galluzzi、意大利基因组医学研究所Ilio Vitale共同通讯在Cancer cell发表题为“The hallmarks of cancer immune evasion”的综述,阐述了肿瘤免疫逃逸的关键机制:伪装、胁迫和细胞保护(Camouflage, Coercio...
Hallmarks of Cancer: New Dimensions 近期在Cancer Cell上发表了题为The hallmarks of cancer immune evasion的综述,系统地介绍了从「三 E」模型到「三 C」框架下癌症免疫逃逸的关键标志,并讨论了针对这些免疫逃逸机制的有前景的策略。 一、「3E」 ...
2. Immune checkpoint therapy—current perspectives and future directions. doi.org/10.1016/j.cell. 3. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. doi.org/10.1038/nm730 4. The diverse functions of the PD1 inhibitory pathway. doi.org/10.1038/nri.201...
1. DUNN G P, BRUCE A T, IKEDA H, et al. Cancer immunoediting: from immunosurveillance to tumor escape [J].Nat Immunol, 2002, 3(11): 991-8. 2. DHATCHINAMOORTHY K, COLBERT J D, ROCK K L. Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation [J].Front Immunol, ...
2021年2月24日,密歇根大学邹伟平教授团队(杜婉博士和花芳教授为共同第一作者)在Cancer Discovery上发表了题为:Loss of optineurin drives cancer immune evasion via palmitoylation-dependent IFNGR1 lysosomal sorting and degradation的研究论文。 该研究揭示视神经蛋白(optineurin)是调控结直肠癌IFNγ和MHC-I通路完整性...
Cancers can avoid immune-mediated elimination by acquiring traits that disrupt antitumour immunity. These mechanisms of immune evasion are selected and reinforced during tumour evolution under immune pressure. Some immunogenic subclones are effectively eliminated by antitumour T cell responses (a process ...
来自Francis Crick研究所的团队在《Cancer Discovery》(IF=28.2)发表的一项题为“Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer”的研究采用了成像质谱流式(IMC)等多种技术对早期NSCLC患者的肿瘤和正常区域进行了深入的空间和表型分析,揭示了TME的四种主...
免疫逃避(immune evasion)是癌症发生和转移的关键。追踪免疫逃逸的动态过程,有助于阐述其在治疗干预中的潜在应用价值。 免疫逃逸“追踪”研究 最近新加坡国立大学Duke转化免疫学研究所、南洋理工大学、新加坡科技研究局(A*STAR)分子细胞研究所等单位的科学家做了这项“追踪”工作。他们选择了肝细胞癌(Hepatocellular carci...
et al. Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation. Cancer Immunol. Res. 8, 1262–1272 (2020). This study explores how hyperglycaemia drives tumour progression, by increasing O-GlcNAcylation in TAMs to switch on the M2-...
Immune evasion is a feature of HPV-positive head and neck squamous cell carcinoma (HNSCC). Here the authors report that a circular RNA, circE7, encoded by HPV promotes immune evasion in HNSCC by promoting downregulation of galectin-9.