This accumulation of DNA damage, in turn, causes higher incidences and grades of cancer, mainly if these DNA lesions occur in critical genes, such as tumour-suppressor genes or oncogenes [70]. Researchers had thought that the radiosensitivity of cells is directly correlated to the turn-over ...
Many types of cancers express high levels of p97, which are often correlated with poor survival, metastasis, and therapeutic resistance6. Functionally, a number of inhibitors targeting p97 exhibit potent cytotoxicity in these cancers6,7. For example, Eeyarestatin I (Eer I), the first developed...
supporting a role for ID1 in the maintenance of the protumor phenotype of TAMs. Furthermore, the enhanced expression of ID1 in TAMs exerts a protumoral role by driving the acquisition of cancer stemness properties and excluding the CD8+cytotoxic T lymphocyte...
As the prognostic value of NGS has been proven in operable breast cancer (stages I and II), in which decisions about systemic therapy usage and its regimen need to be made, histological grade could be incorporated in the TNM system to improve its ability to stratify cases into risk-...
6. a MMPs: as it is their complex with the ECCs that degrades the ECM, we visualise them here in the vicinity of the ECCs. b, c CAFs &TGF-\(\beta \): visualised over the half x-domain. In both panels, the isosurface reveals that, according to the ICs (45)–(49), the CAFS...
Varying grades of epithelial atypia in the pancreatic ducts of humans.Arch Pathol Lab Med 1994; 118: 227–234. PubMed CAS Google Scholar Mizumoto K, Inagaki T, Koizumi M, Uemura M, Ogawa M, Kitazawa S, Tsutsumi M, Toyokawa M, Konishi Y. Early pancreatic duct adenocarcinoma.Hum Pathol ...
Blood samples were collected from 8 ovarian cancer patients (mixed tumor subtypes, tumor grades =1-3 and tumor stages = 1-4) and 8 healthy female donors. After centrifugation, equal volumes of serum were separated, and total RNA was extracted using a miRNeasy Serum/Plasma Advanced Kit (...
1 Its pathogenicity is mediated by its zinc-dependent metalloprotease toxin named B fragilis toxin, which degrades colon E-cadherin, causing epithelial barrier damage, oxidative damage, and inflammatory immune responses leading to colon cell hyperproliferation.45 The implication of these associations ...
Overexpression of CD166 in papillary thyroid carcinoma (PTC) was independently associated with a shorter progression-free survival, higher nodal and tumor stages suggesting that CD166 may be a potential therapeutic target to treat PTC [28]. CD166 has been implicated as CSCs marker in many cancer...
Furthermore, the prioritized DEGs were used to determine the involved GO enrichment and KEGG signaling pathways at various stages of the breast cancer. The recurrence survival rate analysis of the identified gene biomarkers was conducted based on Kaplan–Meier methodology. Furthermore, the identified ...