Cancer in one breast puts you at higher than average risk of developing cancer in the other breast. This is true even if you are still being treated with an estrogen blocker. Be sure to have regular checkups and mammograms.Additional info...
A random phase III trial led by Canadian trial group NCIC CTG showed that risk of breast cancer in menopausal women dropped by 65 percent compared to a placebo when patients usedexemestane, an oral drug that decreases the body's production of estrogen, the hormone that has been implicated in ...
A study in Elsevier's Canadian Journal of Cardiology offers important insights for the long-term health management of breast cancer survivors
A New Anti-estrogen Discovery platform identifies FDA-Approved imidazole anti-fungal drugs as Bioactive compounds against ERα expressing breast Cancer cells. Int J Mol Sci. 2021;22(6):2915. Article CAS PubMed PubMed Central Google Scholar Shen PW, Chou YM, Li CL, Liao EC, Huang HS, ...
(e.g. beta-blocker and diuretics), we considered the individual components separately, with specific splitting rules applied for sex hormones (Supplementary Fig.10). Chronic exposure to concomitant medication was coded as: (i) “yes” if the patient had received at least three months of the ...
Using the online, publicly available web server (http://endocrinedisruptome.ki.si.), the metabolites were computationally screened and evaluated for binding to 14 nuclear receptors, including the androgen receptor (AR); estrogen receptors (ER) α and β; glucocorticoid receptor(GR); liver X recep...
Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an aromatic, estrogen receptor blocker moiety. Methods for synthesizing these compounds and using them in the ...
Article05 June 2023 Introduction The emergence of immunotherapy has revolutionized the paradigm of cancer treatment with immune checkpoint blockers (ICB). These monoclonal antibodies, blocking immune checkpoint-relevant molecules such as PD1, PD-L1, and CTLA-4, exert their effect by inhibiting the imm...
Psychological stress or the perception of a lack of control (helplessness) can release stress hormones that increase the risk of tumor growth and metastasis, while beta blockers may decrease rates of recurrence (for example, in women with breast cancer) [162,163,164]. Furthermore, both ...
Long non-coding RNAs (lncRNAs) involved in metabolism are recognized as significant factors in breast cancer (BC) progression. We constructed a novel prognostic signature for BC using metabolism-related lncRNAs and investigated their underlying mechanism