While PCGR is intended for reporting and analysis of somatic variants detected in a tumor, CPSR is intended for reporting and ranking of germline variants in protein-coding genes that are implicated in cancer predisposition and inherited cancer syndromes....
(4) Primary surgery planned in keeping with National Institute for Health and Care Excellence (NICE) UK guidelines. (5) Agreement to be followed up at a TRACERx site. (6) Performance status (ECOG) 0 or 1. (7) Minimum tumour diameter of at least 15 mm to enable sampling of at ...
Expression analysis of the colibactin gene cluster coding for a novel polyketide in Escherichia coli. FEMS Microbiol. Lett. 275, 255–262 (2007). Article CAS PubMed Google Scholar Oliero, M. et al. Prevalence of pks + bacteria and enterotoxigenic Bacteroides fragilis in patients with ...
APAF1-binding long noncoding RNA promotes tumor growth and multidrug resistance in gastric cancer by blocking apoptosome assembly. Adv. Sci. 9, e2201889 (2022). Article MathSciNet Google Scholar Wei, X. et al. METTL3 preferentially enhances non-m(6)A translation of epigenetic factors and ...
RNA polymerase II transcribe a group of non-coding RNAs, such as miRNAs, which regulates gene expression. MiRNAs are comprised primarily of 18–22 nucleotides and bound to mRNAs. This binding prevents mRNA from attaching to ribosomes and leads to mRNA degradation via the RNA-induced silencing co...
Noncoding RNAs mRNAs: Messenger RNAs EVs: Extracellular vesicles EMT: Epithelial-mesenchymal transition EpCAM: Epithelial cell adhesion molecule scNGS: Single-cell next-generation sequencing cfDNA: Cell-free DNA PCR: Polymerase chain reaction qPCR: ...
It was also reported that miR-141 could be counteracted by long noncoding RNA (lncRNA) HCG18, therefore, the YAP/TAZ expression level was upregulated and promoted tumor cell migration and invasion in gastric cancer [66]. The prognostic value of the miR-141/YAP1 pathway was also proved ...
Mechanically, CBSLR interacted with YTHDF2 to form a CBSLR/YTHDF2/CBS signaling axis that decreased the stability of CBS mRNA by enhancing the binding of YTHDF2 with the m6A-modified coding sequence (CDS) of CBS mRNA. Furthermore, under decreased CBS levels, the methylation of the ACSL4...
Combined with these results, we believe that by targeting proteasome coding genes of cell cycle check points, bortezomib could block the proteasome degradation of p21 and p27, hinder the formation of cyclin/CDK complex, arrest the cell cycle in G0/G1 phase, and then inhibit the proliferation ...
(2013), this study first demonstrates recurrent somatic non-coding mutations driving tumorigenesis. The mutations generate de novo consensus binding sites for the ETS family of transcription factors in the TERT gene promoter. Article CAS PubMed PubMed Central Google Scholar Liu, X. et al. Highly...