Chemotherapy often generates intratumoral senescent cancer cells that strongly modify the tumor microenvironment, favoring immunosuppression and tumor growth. We discovered, through an unbiased proteomics screen, that the immune checkpoint inhibitor programmed cell death 1 ligand 2 (PD-L2) is highly upregul...
Chemotherapy rescued her! Part 1: Disaster – twenty months after surgery! Part 2: Chemotherapy rescued her. Part 3: After chemotherapy she opted for CA Care Therapy. Due to the massive metastasis as shown in the PET scan done on 10 December 2021, Lucy had no choice but to proceed with ...
But after surgery, you need to go for chemotherapy. Chemotherapy is not going to cure you either! A lady from Surabaya was asked to go for chemotherapy for her gallbladder cancer. She refused. Why? She said, My 39-year-old son had lung cancer. He died after undergoing 5 or 6 cycles ...
Changes in physical fitness in acute leukemia patients during chemotherapy Wenkui Xu ,Zhangjie Li &Rong Hu Article 15 February 2025|Open Access Comprehensive bioinformatic analysis reveals prognostic significance and functional insights of candidate gene expression in colorectal cancer ...
[73,95,96]. However, some research suggests that there may not be a significant difference in CTC counts between blood samples collected before and after chemotherapy, possibly due to variations in CTC identification and treatment strategies [29,93,197]. In addition to quantitative analyses, the...
Chemotherapy Although therapeutics based on 5-fluorouracil with oxaliplatin or irinotecan markedly kill CRC cells, a proportion of tumor cells still survive, leading to drug resistance and disease progression [7]. Glycolytic metabolism contributes to the resistance to chemotherapy. Research indicated that ...
Chemotherapy and irradiation are mainly effective against proliferating cells. It is likely that dormant tumor cells comprise both CSC and non-CSC populations [86]. Study from the Massague J laboratory demonstrated that latency competent cancer (LCC) cells show stem-cell-like characteristics and ...
angiogenesis, progression, glucose metabolism or drug resistance of OC cells by PI3K/AKT pathway [194,195,196,197,198,199,200,201,202,203,204,205,206,207]. Some clinical trials of PI3K/AKT inhibitors or in combination with chemotherapy drugs listed in Tables2and3may help relieve the patients...
Mortality from breast cancer is almost exclusively a result of tumor metastasis and resistance to therapy and therefore understanding the underlying mechanisms is an urgent challenge. Chemotherapy, routinely used to treat breast cancer, induces extensive
NE-diff is increasingly recognized as a mechanism of acquired resistance to targeted therapies in many cancers. Detection of NE-diff is clinically important because high-grade neuroendocrine tumors often respond to platinum-based chemotherapy, but spatial heterogeneity and sampling error make the pathologi...