extra-cellular matrix degradation and motility factor up-regulation [89]. Hypoxia often leads to increased aggressiveness and tumor resistance to chemotherapy and radiation [90]. All the findings about the effects of hypoxia and starvation on the state of bounded cellular constellations were taken...
which complicates rational treatment decisions [6]. At present, clinical management of OC is mainly based on maximum cytoreductive surgery and combinatorial chemotherapy with cisplatin and paclitaxel [5]. Recently, the use of anti-angiogenic agents and poly-ADP-ribose polymerase (PARP) inhibitors for...
Key findings come also from Henriksen et al., that investigated post-adjuvant chemotherapy ctDNA status in stage III colon cancer patients [141]. In particular, ctDNA presence was associated with disease recurrence postoperatively also in patients treated with adjuvant chemotherapy. Only patients who ...
II and III colon cancer [135]. Data showed that ctDNA-positive patients at postoperative day 30 had a higher recurrence rate compared with those who were ctDNA negative after surgery. Similarly, ctDNA positivity in patients treated with adjuvant chemotherapy was associated ...
Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer. Oncotarget. 2015;6(12):10253–66. PubMed Google Scholar Gernapudi R, Yao Y, Zhang Y, Wolfson B, Roy S, Duru N, et al. Targeting exosomes from preadipocytes inhibits ...
Chemotherapy drugs cause acute side-effects, including nausea, fatigue, vomiting, fever, diarrhea, and sensitivity to sunlight. Certain drugs are associated with specific side effects. 5-fluorouracil may cause low white blood cell count, ulcers, and visual problems. Mitomycin is associated with bone...
To test the combination effect of standard chemotherapy with ascorbate, Espey et al. [209] have shown that synergistic cytotoxic effects can be achieved with gemcitabine and ascorbate in pancreatic cancer both in vitro and in a nude-mouse model. These data provide support for investigating the ...
‘liquid biopsies’ refers to the analysis of tumour cells and molecules providing information about the disease in samples of body fluids like blood or urine [11]. Such samples can be obtained in a minimally invasive or non-invasive way; therefore, liquid biopsies are particularly suitable for ...
The SUPR effect allowed for a fivefold increase in the accumulation of a liposomal chemotherapy (DaunoXome), leading to more effective therapy than PIT alone or daunorubicin [130]. In addition, PIT greatly reduces the speed of the blood, while the blood vessel is not damaged or thrombosed. ...
“Here, we sit in early 2024, when there still have not been the kinds of changes we want to see in this disease, but it’s now nice to have a new treatment option at our disposal,” said Wainberg, who is a professor of medicine at the University of California, Los Angeles (UCLA)...