Normal (MCF12A) and cancer (U251 and HeLa MR) cells exhibit very different metabolic (XTT), proliferative, and cell cycle effects after MNNG exposure.Maithili, Gupte
Cells transfected with siRNAs, precursor miR-15b and miR-15b inhibitor or controls as described, were trypsinised, washed with PBS and subjected to cell-cycle analysis using NucleoCounter NC-3000 (Chemometec, Allerød , Denmark). The analysis method was a two-step cell-cycle analysis in which...
2025年1月2日,来自美国德州大学MD安德森癌症中心的Honami Naora团队在Cancer Cell上在线发表题为Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10的文章,旨在揭开NET在大网膜转移前生态位形成中的作用,特别是它们如何通过招募...
2025年1月2日,来自美国德州大学MD安德森癌症中心的Honami Naora团队在Cancer Cell上在线发表题为Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10的文章,旨...
Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage Despite being a hallmark of cancer, the identification of targetable vulnerabilities of aneuploid cancer cells remains limited. Here, the authors develop RPE1-hTERT cell lines with varying degrees of aneuploidy...
Extracellular pH (pHe) evaluated in normal cells as 7.4 and was 6.5 in tumor cells. While in cytosol due to the similar pH range for both cell types, there is no proper distinction for diagnostic purposes [9]. The extracellular space of tumor cells with a pH difference of one unit ...
Cancer stem cells are the malignant counterparts of normal somatic stem cells that can maintain quiescence, divide symmetrically for self-renewal, and divide asymmetrically to repopulate the tumor cell population within a tumor. AI generated definition based on:Fetal and Neonatal Physiology (Fifth Editio...
近日,来自美国德克萨斯大学西南医学中心(UTSW)的Sean J. Morrison团队等在Cancer Discovery杂志上合作发表了一篇题为Non-selective β adrenergic receptor inhibitors impair hematopoietic regeneration in mice and humans after hematopoietic ...
Linking cell mechanical memory and cancer metastasis In this Perspective, Cambria et al. propose that mechanical cues within the primary tumour that are known to promote metastasis imprint a persistent phenotype on cancer cells through mechanical memory to further facilitate cancer metastasis at distant ...
How Do Cancer Cells Differ from Normal Cells? In normal cells, hundreds of genes intricately control the process of cell division. Normal growth requires a balance between the activity of those genes that promote cell proliferation and those that suppress it. It also relies on the activities of...