Male breast cancer: a report of 127 cases at a Moroccan institution Male breast cancer (MBC) is a rare disease representing less than 1% of all malignancies in men and only 1% of all incident breast cancers. Our study detai... M Bourhafour,R Belbaraka,A Souadka,... - 《Bmc Research...
Breast cancer, the world’s most commonly diagnosed cancer, is a heterogeneous disease that demands appropriate diagnosis for better patient management. Thus, the understanding of the molecular mechanisms of tumor heterogeneity, as well as the characteri
Department of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Melissa A. Troester Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA Nadine Tung...
Although AHR was found in many cancers (24% of all tumors) and specific tumor types (for example, 55% of cases of malignant lymphoma) (Extended Data Fig. 9c), it contributed to a minority of UPD events, most of which were progressive (31% P-UPD versus 1% AHR-UPD by total width) ...
Pancreatic cancer (PC) is one of the most aggressive recalcitrant malignancies and portends a high mortality rate [1]. Based on the National Cancer Institute 2021 estimates, PC accounts for 3.2% of all new cancer cases and 7.9% of all cancer-related deaths [2]. In contrast to the steady...
Other cancers may account for another ~ 14750 new HER2A cases. We explored the genomics of these HER2A tumors to better understand similarities and differences to HER2A breast cancer, and potential for therapeutic intervention. Table 3 Estimated HER2A patient population size based on HER2A ...
The North Carolina General Assembly and the people of North Carolina have presented the University of North Carolina at Chapel Hill, the UNC Lineberger Comprehensive Center, the North Carolina Hospital, and UNC Health Care with an astounding opportunity and responsibility. We embrace that opportunity ...
In cases where autophagy possesses a tumor-suppressor role, the focus is on the induction of this molecular mechanism. For instance, Beclin-1 upregulation induces autophagy and can reduce the viability and progression of breast cancer cells in vivo. Therefore, the delivery of Beclin-1 by polymeri...
In many cases, patients with increased copy numbers had significantly increased hazard ratio and reduced survival times, suggesting that super-enhancer copy numbers may be of prognostic value (Fig. 2b). Taken together, these data suggest that the SEs we identified in OVCAR3 cells are ...
point estimates of survival (e.g., at 12-months) using a Weibull-based parametric approach approximately doubles the number of trials in which informative confidence intervals can be obtained. In cases in which parametric and nonparametric approaches can be compared directly, we find that a 50-pa...