Non-small cell lung cancers (NSCLC) account for 85–90% of all lung cancers. As drug resistance critically impairs chemotherapy effectiveness, there is great need to identify new therapeutic targets. The aims of this study were to investigate the prognos
To define the mechanisms underlying the tumor regression phenotype caused by IRE1α loss, we performed RNA-seq of mCherry+ malignant epithelial cells sorted from IRE1αWTor IRE1αKOtumors at two different time points of growth: day 10, when tumor growth was comparable, and day 14, when tum...
Heatmaps were made using the Pheatmap (version 1.0.12) and RColorBrewer (version 1.1-2) packages, and the Venny web portal (version 2.1) was used to make all Venn diagrams. Differential gene expression (DGE) was performed on non-normalized counts using the standard DESeq2 package (version...