The course introduces the molecular biology of cancer (oncogenes and tumor suppressor genes) as well as the biologic hallmarks of cancer. The course also describes the risk factors for the major cancers worldwide, including lung cancer, breast cancer, colon cancer, prostate cancer, liver cancer,...
The frequent, chronic administration of chemotherapy at low, non-toxic doses, with no prolonged drug-free breaks. About this article Cite this article Bast, R., Hennessy, B. & Mills, G. The biology of ovarian cancer: new opportunities for translation.Nat Rev Cancer9, 415–428 (2009). ht...
Department of Cancer Stem Cell Biology, Osaka University Graduate School of Medicine, Osaka, Japan Yoshihiro Oka Department of Clinical Laboratory and Biomedical Sciences, Integrated Health Design Initiative (IHDi), Osaka University Graduate School of Medicine, Osaka, Japan Yusuke Oji Department of Cancer...
Thus, CMS should be used as a starting point to further CRC biology research in order to develop novel biomarkers and rational combinatorial therapies. More recently, single-cell studies in CRC have attempted to provide a global view of the CRC landscape [18, 19]; however, in-depth ...
The analysis of surface membrane and intracellular antigens in breast carcinoma cells has been greatly accelerated by the discovery of monoclonal antibodies produced by somatic cell hybridization1. Such antibodies provide a large supply of a reagent whic
97-101 Unequal access to timely, high-quality treatment explains much of the survival disparity, although differences in tumor biology, comorbidities, and response to treatment also contribute. In a study based on a large national sample of nonelderly patients with early stage breast cancer, ...
Precision oncology is likely to benefit from integrated diagnostics84,85 (e.g. radiogenomics, which combines radiomics and genomics analyses) to provide robust computational tools for investigating cancer biology, as well as for predicting treatment response (Fig. 5). The solution includes large-...
Secular changes in both the timing of pubertal milestones and the prevalence of pediatric obesity, two factors which influence future breast cancer risk in women, have made research into the biology of the ADOL breast all the more compelling. Previous studies in OB children have identified ...
21Serous carcinomas are graded in a two-grade system befitting their biology. High-grade serous carcinomas, including both classic appearing and those with SET features (solid, endometrioid-like, and transitional) carry a high frequency of mutations inTP53.22-24Low-grade serous carcinomas are ...
sample quality and processing to reduce the risk of errors in molecular biology tests [95]. Furthermore, practicing pathologists need to go beyond diagnosis and classification in order to produce information that will be required to guide treatment accurately and to do so in a timely manner [96...