However, only a single copy of the gene is mutated in tumours, raising the possibility that the mutations do not result in a simple loss of function. Here we show that cancer-associated IDH1 mutations result in a new ability of the enzyme to catalyse the NADPH-dependent reduction of alpha-...
Here we show that cancer-associated IDH1 mutations result in a new ability of the enzyme to catalyse the NADPH-dependent reduction of α-ketoglutarate to R(-)-2-hydroxyglutarate (2HG). Structural studies demonstrate that when arginine 132 is mutated to histidine, residues in the active site ...
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009; 462:739–744. Article CAS PubMed PubMed Central Google Scholar Fendt SM, Bell EL, Keibler MA, et al. Reductive glutamine metabolism is a function of the alpha-ketoglutarate to citrate ratio in cells. Nat Commun 2013; ...
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Nature, 462 (2009), pp. 739-744 Google Scholar 12 X. Xu, J. Zhao, Z. Xu, B. Peng, Q. Huang, E. Arnold, J. Ding Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of ac...
Dang L, White DW, Gross S et al (2010) Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 465:966 ArticleCASPubMedPubMed CentralGoogle Scholar De Luca A, Fiorillo M, Peiris-Pages M, Ozsvari B, Smith DL, Sanchez-Alvarez R et al (2015) Mitochondrial biogenesis is required ...
The article presents a supplement to the article "Cancer-associated IDH1 mutations produce 2-hydroxyglutarate" that was published in the 2010 issue, which discusses accumulation of R(—)-2-hydroxyglutarate (2HG) as a possible cause of on... Dang,Lenny,White,... - 《Nature》 被引量: 3355发...
16 Dang, L.et al.Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.Nature462, 739-744, doi:10.1038/nature08617 (2009). 17 Gross, S.et al.Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations.The Journal of...
Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition.doi:10.1101/gad.226613.113.AMLBrd4inhibitionIDHmutantstargetedtherapytumormaintenanceSomatic mutations in the isocitrate dehydrogenase (IDH) genes IDH1 and IDH2 occur frequently in acute myeloid leukemia (...
High MGMT activity in tumor tissue is associated with resistance to alkylating agents. MGMT activity is controlled by a promoter sequence, and methylation of the CpG island in the promoter silences the gene in cancer cells, so that these cells no longer produce MGMT. In addition, as described...
Laukka, T., Myllykoski, M., Looper, R. E. & Koivunen, P. Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases.J. Mol. Biol.430, 3081–3092 (2018). Dang, L. et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.462, ...