the use of PSA has also led to over-diagnosis and over-treatment of prostate cancer resulting in controversy about its use for screening. Prostate specific antigen also has limited predictive accuracy for predicting outcomes after
Yanagisawa and associates (2018) noted that Wilms' tumor 1 (WT1) is a tumor-associated antigen highly expressed in cancer. These researchers examined the safety of WT1-peptide pulsed DC (WT1-DC) vaccine in combination with chemotherapy in patients with surgically resected pancreatic cancer. A tota...
Nanoparticles stabilize vaccines and improve antigen recognition and presentation, resulting in high tumor penetration or accumulation, effective co-distribution of drugs to the secondary lymphatic system, and adaptable antigen or adjuvant administration. Such vaccine-like nanomedicines have the ability to ...
2-thiouridine SCLC: Small cell lung cancer ssRNA: Single-strand RNA TAA: Tumor-associated antigen TCGA: The Cancer Genome Atlas TCR: T cell receptor TGS: Third-generation sequencing Th cell: T helper cell TLR: Toll-like receptor UTR: Untranslated region ZIKV: Zika virus ...
Receptors expressed by T cells are responsible for recognizing a variety of antigens from pathogens, tumors, and the environment, and maintaining immune memory and tolerance [158]. Regulatory T cells (Tregs) are key regulators of immune control, the suppression of which largely rely on FOXP3 ...
Sheikh NA, Jones LA: CD54 is a surrogate marker of antigen presenting cell activation. Immunol Immunother 57:1381-1390, 2008 Higano CS, Schellhammer PF, Small EJ, et al.: Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with...
vp: Viral particles, pfu: Plaque-forming unit, inf.U: Infectious units, IT: Intratumoral, IV: Intravenous, IP: Intraperitoneal, ID: Intradermal, OS: Overall survival, ORR: Overall survival rate, PFS: Progression free survival, CEA: Carcinoembryonic antigen, MUC: Mucin, NSCLC: Non small cell ...
81342 TRG@ (T cell antigen receptor, gamma) (eg, leukemia and lymphoma), gene rearrangement analysis, evaluation to detect abnormal clonal population(s) 81400 Molecular pathology procedure, Level 1 81401 Molecular pathology procedure, Level 2 81402 Molecular pathology procedure, Level 3 81403 Molecula...
Some aspects of the invention relate to vaccines, vaccinations and other means of stimulating an antigen specific immune response against a tumor in individuals. Such vaccines comprise neoantigens resulting from frameshift mutations that bring out-of-frame sequences of the ARID1A, KMT2B, KMT2D, PI...
The anti-CSF1R antibody, optionally along with a CD40 agonist, may be combined with a combinatorial approach that targets multiple elements of the immune pathway, such as one or more of the following: at least one agent that enhances tumor antigen presentation (e.g., dendritic cell vaccine, ...