Some intracranial tumors arise from nonneuronal and nonglial cells, such as Meningiomas and Hemangioblastomas, which originate from the meninges and the brain’s blood vessels, respectively. Meningiomas are the most common intracranial tumors, but despite their occurrence directly affecting the brain,...
In a large-scale prospective study run across 12 sites in Germany and involving 463,094 women and 119 radiologists, AI-supported screening increased breast cancer detection rates by a significant margin without affecting the recall rate. Nora Eisemann ...
In cancer, the impact on cellular fitness of copy-number gains affecting collaterally-amplified genes remains poorly understood compared to oncogenes. Here, the authors integrate genomic data from tumours and cell lines and identify a class of ‘Amplification-Related Gain Of Sensitivity’ (ARGOS) ge...
Glioblastoma tumors make their own blood supply, which helps them grow. It's easy for them to invade normal brain tissue. How Common Is Glioblastoma? Brain cancersand those affecting thecentral nervous system(CNS) are the fifth most common cancers in the U.S.Of the almost 90,000 brain tumo...
"It's a bit like if you give 10 different chefs the same recipe, they could end up preparing multiple variations of the same dish. "These changes can be minor, or major. In the case of glioma, they're affecting a process that's essential for the maturation and function of brain cells...
The absence of USP32 will also affect the structure and function of intracellular lysosomal vesicles and the transport of nuclear endosomes, thus affecting the occurrence of some diseases [35]. The structure and activities of USP32 Human USP32 is composed of 1604 amino acids [23] and has an ...
embryological development and damaged tissue reparation [40]. Cells performing collective migration share many biological characteristics with independently migrating cells but, by affecting one another mechanically and via signaling, these cell groups are subject to additional regulation and constraints [...
, and tumor growth compared to controls under hypoxic conditions, mildly affecting the angiogenic response.191Breast cancer cells expressing CPT1C showed increased FAO, ATP production, and resistance to glucose deprivation or hypoxia.192However, experimental results have shown that HIF-1α and HIF-2...
Glucocorticoids inhibit macrophage differentiation towards a pro-inflammatory phenotype upon wounding without affecting their migration. Dis. Model. Mech. 12, dmm037887 (2019). Article CAS PubMed PubMed Central Google Scholar Lu, Y. et al. Glucocorticoid receptor promotes the function of myeloid-...
Mechanisms of Xiaozheng decoction for anti-bladder cancer effects via affecting the GSK3β/β-catenin signaling pathways: a network pharmacology-directed experimental investigation Article Open access 22 August 2023 Introduction Bladder cancer is the seventh most common cancer in men, wherein urothelial...