Several benzodiazepines also interact with site 3, flurazepam interacts with site 2, while alprazolam and flumazenil seem to be more specific to site 1 only. This particular type of ligand promiscuity is very likely to be missed in standard assays aimed at refining interactions with a single ...
chemotypes have been observed previously, but have not yet been systematically studied. Several benzodiazepines also interact with site 3, flurazepam interacts with site 2, while alprazolam and flumazenil seem to be more specific to site 1 only. This particular type of ligand promiscuity is very ...