To boost your B1 levels, you can try increasing your consumption of beef liver, eggs, pork, nuts, and seeds (if tolerated) to increase your thiamine levels. However, while I love the theory that we should get all of our nutrients from foods, that’s not always possible — especially for...
cancer is the first or second leading cause of death in 112 countries under 70 years of age [1]. Cancer is an acute problem in both developed and developing countries due to the aging and growing populations, accelerated socioeconomic
Downregulation of Caveolin-1 (cav-1) in Systemic Sclerosis Plays a Key Role in the Fibrotic Process and can be Reversed by Cell Permeable Recombinant Cav-1 PeptidesM. Musick
HU-331 exerts a potent antitumoral activity by targeting DNA polymerase II, while VCE-003 has been identified as an immunosuppressant that exerts a protective action in models of multiple sclerosis (the Theiler's murine encephalomyelitis virus and experimen- tal autoimmune encephalomyelitis) through a...
Some of the both natural and synthetic cannabinoids were used clinically in multiple sclerosis for muscle spasm and pain, recurrent glioblastoma multiform, neuropathic pain, and protective agents in brain trauma [8]. For instance, 1′,1′-dimethylheptyl-Δ8-tetrahydrocannabinol-11-oic acid was ...
When this failure to discriminate between self and non-self occurs and the immune system reacts against self antigens, an autoimmune disorder may arise. Autoimmune diseases, or diseases having an autoimmune component, include rheumatoid arthritis, multiple sclerosis, systemic lupus erythromatosis (SLE...
With increasing incidence and geography, cancer is one of the leading causes of death, reduced quality of life and disability worldwide. Principal progress in the development of new anticancer therapies, in improving the efficiency of immunotherapeutic t
Aberrant insulin-like growth factor 1 (IGF-1) signaling has been proposed as a contributing factor to the development of neurodegenerative disorders including diabetic neuropathy, and delivery of exogenous IGF-1 has been explored as a treatment for Alzheimer's disease and amyotrophic lateral sclerosis...
remodelling of muscle tissue.187,189HDAC4, in particular, is necessary for maintaining skeletal muscle homoeostasis and function. And it has been identified as a potential target for treatment of skeletal muscle disorders such as cancer cachexia, amyotrophic lateral sclerosis (ALS) or muscular ...
Indeed, miR-155 has been identified as an important regulator of inflammatory pathways, with dysregulated expression contributing to the pathogenesis of cancers, pulmonary disorders, multiple sclerosis and numerous other inflammatory autoimmune diseases [155,156,157]. More specifically, Zhao et al. found...