Highlights We tested how behaviour, morphology and environment influence passive dispersal. Passive dispersal events are both phenotype and context dependent. Most aerial dispersal is by mites engaged in chain-
phenotype in primary intestinal fibroblasts. This pro-inflammatory polarization was found to be interleukin 1α (IL-1α) signaling dependent, as inhibition with an IL-1 receptor (IL1R1) antagonist (anakinra) reversed it. Furthermore, to prove the critical role played by CAFs in acquired radiores...
Experimental microbiome perturbations are usually impossible in humans, and large-scale observational studies are confounded by host-associated factors, such as host genetics and lifestyle, making it difficult to identify causative microbial mechanisms for a given phenotype37. Animal models are tractable ...
Another study found that in comparison with milk protein, soy protein increased the microbial diversity throughout the gut of hamsters.52 Increased microbial diversity in humans is associated with a “lean” phenotype5 and has been shown to be associated ...
Precursor cells of osteoblasts and osteoclasts were analyzed within a controlled laboratory environment. The trabecular bone phenotype in C3aR-/-C5aR-/- mice became more pronounced by the 10th week. In vitro experiments demonstrated that C3aR-/-C5aR-/- cultures, in comparison to wild-type ...
In patients with hemophilia A, FIX-FIAV improves FVIII-equivalent activity and coagulation activity in the plasma, thereby diminishing the hemophilia A phenotype. Consequently, FIX-FIAV might prove to be a suitable therapeutic option for HA patients, irrespective of whether they are receiving ...
1g, h). These observations in conjunction with observations on the F508G-CFTR-2PT phenotype (Fig. 2c–g and Supplementary Fig. 1e) support the notion that 2PT-mediated allosteric conformational rescue of the F508G-CFTR requires stabilization of fast atomic motions at both CL1- and CL4-NBD1...
There are many postharvest phenotypes that influence the quality and shelf-life of crops that are poorly understood at the molecular level. These traits may be influenced by the activity of multiple genes and their alleles, and how their expression is altered by the environment (see “Identifying...
This phenotype could be explained by mice acclimating to the cage and thus reflective of the true normal behavior of mice during the day, or it could be explained by mice experiencing some form of weariness in this assay system. Others have shown that this physiology, described as “freezing...
coli and suggested a membrane integrity phenotype that we describe as "QAC-dependent" when we visualized and analyzed these cells using scanning electron microscopy (SEM). This study also compares the use of another impermeant fluorescent dye as a replacement for PI, SYTOX Blue, and revealed that...