Highlights We tested how behaviour, morphology and environment influence passive dispersal. Passive dispersal events are both phenotype and context dependent. Most aerial dispersal is by mites engaged in chain-forming behaviour. Regarding morphology, aerial dispersal relates to body shape rather than size...
Genotype-phenotype correlation studies revealed that individuals with a single-copy MAB21L1 missense variant demonstrated solely ocular anomalies (BAMD), in contrast to those with two copies, who displayed both ocular and extraocular manifestations.Heterozygous pathogenic alterations in MAB21L1's genetic ...
phenotype in primary intestinal fibroblasts. This pro-inflammatory polarization was found to be interleukin 1α (IL-1α) signaling dependent, as inhibition with an IL-1 receptor (IL1R1) antagonist (anakinra) reversed it. Furthermore, to prove the critical role played by CAFs in acquired radiores...
Experimental microbiome perturbations are usually impossible in humans, and large-scale observational studies are confounded by host-associated factors, such as host genetics and lifestyle, making it difficult to identify causative microbial mechanisms for a given phenotype37. Animal models are tractable ...
Another study found that in comparison with milk protein, soy protein increased the microbial diversity throughout the gut of hamsters.52 Increased microbial diversity in humans is associated with a “lean” phenotype5 and has been shown to be associated ...
1g, h). These observations in conjunction with observations on the F508G-CFTR-2PT phenotype (Fig. 2c–g and Supplementary Fig. 1e) support the notion that 2PT-mediated allosteric conformational rescue of the F508G-CFTR requires stabilization of fast atomic motions at both CL1- and CL4-NBD1...
This phenotype could be explained by mice acclimating to the cage and thus reflective of the true normal behavior of mice during the day, or it could be explained by mice experiencing some form of weariness in this assay system. Others have shown that this physiology, described as “freezing...
We reveal the existence of a p53-driven hierarchy, where cancer cells with a gain-of-function (GOF) mutant p53 educate a dominant population of CAFs that establish a pro-metastatic environment for GOF and null p53 cancer cells alike. We also demonstrate that CAFs educated by null p53 cancer...
Gene-environment interactions appear to play a role in both Alzheimer's Disease and Obsessive-Compulsive Disorder, according to preceding research. A broader investigation into this shared mechanism is necessary, involving a larger study population. This study's results emphasize the necessity...
Evolution of the mutator strains All WT strains have been cloned 20 times and propa- gated for 100,000 further generations in the same constant environment. Among these 20 populations, 10 were carry- ing the mutator phenotype (point mutation rate increased 100× - see "Methods") while the ...