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First, different detection methods for this index can give different results, which leads to "misclas- sification" of PD-L1 status for some patients [13]. Specifi- cally, the manual evaluation of TPS by pathologists has practical limitations including intra/inter-observer bias, variation in ...
We have shown that the type 1 diabetes GRS can identify individuals likely to have monogenic autoimmunity, helping both diagnostic testing and novel monogenic autoimmunity gene discovery. Individuals with monogenic autoimmunity have a different clinical course to those with polygenic type 1 diabetes and ...
The investigation aimed to identify disparities in diagnosis and treatment protocols between patients with and without significant menstrual bleeding.We compiled historical data on adolescent patients (ages 10-19) diagnosed with AUB, including specifics of their follow-up care, final control procedures, ...
The primary goal of imaging for lymph node metastasis of unknown primary origin is to identify the source tumor or confirm its absence, thereby enabling the correct diagnosis and the most suitable treatment plan. The authors delve into diagnostic imaging procedures aimed at discovering the primary ...
benefit is conferred at the level of individual patients due to drug interaction within tumor cells, and in the latter case, benefit is conferred only at the level of patient populations due to variability in drug responses. The distinction influences the interpretation of clinical trial data, the...
known to the best of our knowledge that conclusively identify the non-endotoxin related sepsis-inducing compounds from bacteria including mycoplasma species. The use of the various shortened lipopeptides used here instead of the parental lipoproteins should be justified by the fact that the stimulation ...
(2003) further identified four decision rules to identify a construct as either formative or reflective: (1) direction of causality from construct to measure implied by the conceptual definition; (2) indicators' interchangeability; (3) covariation among indicators; and (4) construct indicators' ...
GPs are concerned about potential role overlap and desire greater latitude in deciding which patients can be assigned a care manager. GPs think depression can be treated using a chronic care model that includes care managers but that adjusting to the new way of working will take time. ...
The literature was examined systematically, using PubMed and EMBASE databases, to identify pertinent publications until the end of September 2022. To be included, COVID-19 articles required at least one author with an affiliation to the IMSS; this involved no restriction on publication format, ...