A few years ago, a patient was cured of multiple myeloma after being treated for hepatitis C, astounding researchers from the group led by Joaquín Martínez, from the H12O-CNIO Hematological Tumours Clinical Research Unit, a collaboration between the Hospital 12 de Octubre (H12O) and the Nati...
This effect of TNK1 on Ba/F3s was completely dependent on kinase activity, as a kinase-dead point mutation (K148R) abolished transformation (Fig. 4a). Consistent with our observation that UBA-disrupting point mutations inhibit TNK1 activity, we found that TNK1 ΔUBA failed to promote growth...