Conclusion With this method, CBD,CBN,THC and their major metabolite THC-COOH in urine samples could be detected simply, quickly, sensitively and exclusively during toxic analysis. 展开 关键词: cannabis cannabinoids Δ9-THC-COOH urine LC/MS-MS ...
Subsequently, participants underwent a brief health check, received a liquid oral dose of the pharmacological probe (600 mg of CBDV; in line with previous single dose studies of non-psychoactive cannabinoids in adults (e.g., ref. 19) or a matched placebo, both provided by GW Research Ltd...
The cannabinoids most commonly detected in herbal Cannabis materials are shown in Figure 4. For the chemical numbering of cannabinoids, five different nomenclature systems have been used so far,43 but the most commonly used system nowadays is the dibenzopyran numbering, which is also adopted by Che...
Using the 2,000 ng/mL cutoff for urine testing, morphine was not detected in urine from seeds on rolls. Raw poppy seed consumption (found to be unpalatable by participants) resulted in a detectable level in urine during the first 6 hours after consumption. At 20 hours, no morphine was ...
However, NAPQI metabolites, including l-cysteinyl-S-APAP, can be detected in human and mouse blood or urine after ingestion of therapeutic and non-toxic doses of APAP19,24,26. The finding of CYP450 monoxygenase and COX-2 activity and immunoreactivity in the rat and human spinal cord, ...
There seems to be a positive correlation between low calcium intake and vitamin D deficiency, which may contribute to the prevalence of osteoporosis. Bone turnover markers, though unsuitable for osteoporosis diagnosis, are measurable in serum and/or urine, allowing for assessment of dynamic bone ...
Detection and quantification of synthetic cannabinoids (synonym: cannabimimetics) used as a substitute for natural cannabis has been a real toxicological and forensic issue since 2008. On the basis of a short overview of the pharmacological principle, chemical classification, and legal situation in ...
see more While the utilization of these minor cannabinoids is on the rise, there is a noticeable lack of pre-clinical behavioral data concerning their effects, with the preponderance of pre-clinical cannabis research concentrating on the behavioral impacts of delta-9 THC. Male rats were exposed ...
Keywords: cannabinoids; cannabidiol; ∆9-tetrahydrocannabinol; cannabinoid receptors; G-protein- coupled receptors; cancer; apoptosis; inflammation 1. Introduction The flowering herb Cannabis sativa L. (Cannabaceae) has been used in traditional Eastern medicines as an analges...
Synthetic cannabinoidsMDMB-FUBINACAADB-FUBINACAHuman urineMetabolitesLC-QTOF-MSThe structures of two indazole-derived synthetic cannabimimetics, a methyl ester, MDMB-FUBINACA, and an amide, ADB-FUBINACA, differ only in the terminal groups on the side chains. Based upon liquid chromatography-quadrupole ...