Many “nonclassical” growth factors, enzymes, ECM proteins, and other mediators produced by TAMs are involved in the regulation of angiogenesis [42]. These proteins include members of the S100 family, the SEMA family, COX-2, SPP1 (osteopontin), SPARC (osteonectin), Tie-2, and chitinase-like...
We also demonstrate that CAFs educated by null p53 cancer cells may be reprogrammed by either GOF mutant p53 cells or their CAFs. We identify perlecan as a key component of this pro-metastatic environment. Using intravital imaging, we observe that these dominant CAFs delay cancer cell response ...
Many “nonclassical” growth factors, enzymes, ECM proteins, and other mediators produced by TAMs are involved in the regulation of angiogenesis [42]. These proteins include members of the S100 family, the SEMA family, COX-2, SPP1 (osteopontin), SPARC (osteonectin), Tie-2, and chitinase-like...
Cells communicate through direct cell interactions or soluble factors, such as cytokines, growth factors, extracellular vesicles (e.g., exosomes), and extracellular matrix (ECM) components. Among them, cytokines play a fundamental role in CRLM development, since their involvement in tumor initiation,...