How does Camzyos work (mechanism of action)? The heart muscle contains tiny protein fibers, called myosin and actin, that work together to squeeze and relax the heart. In HCM, there is more myosin activity, which leads to more squeezing of the heart muscle and blocking of blood flow. Ca...
The European Commission approved the drug for the treatment of symptomatic NYHA, class II-III obstructive HCM in adult patients, based on the results from EXPLORER-HCM and VALOR-HCM clinical trials, in June 2023. It is the first cardiac myosin inhibitor approved in the European Union (EU). ...
“Unlike previous drugs, Camzyos targets the underlying pathophysiology of HCM, possessing a mechanism that inhibits excessive cross-linking of actin and myosin,” he said. “In other words, by regulating the binding of a proper number of actin and myosin molecules, Camzyos normalizes excessive h...