The protective effect of the PDE-4 inhibitor rolipram on intracerebral haemorrhage is associated with the cAMP/AMPK/SIRT1 pathway.doi:10.1038/S41598-021-98743-WXiao-Liu DongYan-Hui WangJing XuNan ZhangNature Publishing Group
Furthermore, these effects of rolipram could be reversed by the SIRT1 inhibitor sirtinol. In conclusion, rolipram can play a neuroprotective role in the pathological process of ICH by activating the cAMP/AMPK/SIRT1 pathway.doi:10.1038/s41598-021-98743-wXiao-Liu Dong...
Indeed, the routine drugs for the clinical treatment of type 2 diabetes, such as glucagon-like peptide 1 (GLP-1) receptor agonists (lixisenatide, exenatide, exenatide, semaglutide, albiglutide, dulaglutide, and liraglutide) and dipeptidyl peptidase 4 inhibitors (sitagliptin, saxagliptin, alogliptin, ...
《cAMP-AMPK-SIRT1通路在GLP-1受体激动剂改善肝脏脂肪变性中的作用机制》是依托中山大学，由徐芬担任项目负责人的青年科学基金项目。中文摘要 目前尚无药物正式批准用于非酒精性脂肪肝病的临床治疗，GLP-1受体激动剂作为新型降糖药，研究表明其改善肝脏脂质沉积的作用亦十分显著。肝细胞上具有GLP-1受...