背景介绍:Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking...
Target Function:Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 ...
Predicted to be involved in CAMKK-AMPK signaling cascade; activation of protein kinase activity; and protein autophosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol. Is expressed in nervous system; neural retina; and testis. Orthologous to human...
Similarly, an inhibitor of AMPK-ULK1 blocked autophagy, cell growth, and colony formation in prostate cancer cells. Collectively, our findings converge to demonstrate that AR can co-opt the CAMKK2-AMPK-ULK1 signaling cascade to promote prostate cancer by increasing autophagy. Thus, this pathway ...
Thus, CaMKKβ-AMPKα2 signaling constitutes a key tumor suppressor pathway that activates a novel UPA-cancelling mechanism to unmask the cytostatic and pro-senescence functions of C/EBPβ. 展开 DOI: 10.1038/s41388-018-0190-7 年份: 2018 ...
and activation of this signaling cascade promotes dendritic cell survival and increases cytokine secretion from T cells15,16. Both CaM and CaMKK2 can form a complex with AMPK subjecting the bound fraction of AMPK to regulation by calcium rather than AMP13. In addition to functioning as a key...
Jing Z, He X, Jia Z, Sa Y, Yang B, Liu P. NCAPD2 inhibits autophagy by regulating Ca(2+)/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote colorectal cancer. Cancer Lett. 2021;520:26–37. Article CAS PubMed Google Scholar Download references ...
Similarly, an inhibitor of AMPK-ULK1 blocked autophagy, cell growth, and colony formation in prostate cancer cells. Collectively, our findings converge to demonstrate that AR can co-opt the CAMKK2-AMPK-ULK1 signaling cascade to promote prostate cancer by increasing autophagy. Thus, this pathway ...
CaMKK2 overexpression led to increased phosphorylation of AMPK, AKT, and GSK-3尾, and enhanced activation of Nrf2 under MI/R or H/R conditions. Inhibition of AMPK abolished CaMKK2-mediated Nrf2 activation and relevant cardioprotective effect. Restraint of Nrf2 also diminished CaMKK2-mediated ...
Specifically, the glucagon-activated CaMKKbeta/AMPK cascade inhibits acetyl-CoA carboxylase (ACC) activity through the phosphorylation of ACC both in vitro and in vivo. Fasting increases but refeeding decreases the phosphorylation of AMPK and ACC in CaMKKbeta+/+ but not CaMKKbeta-/- mice. Under...