we have established an in vitro model of SCI using neural cells from fetal rats to explore the relationship among them, and found that mechanical injury could promote the intracellular Ca2+ concentration, and the increased Ca2+ level activated autophagy through the CaMKK beta/AMPK/mTOR pathway. ...
In summary, this study is the first to report that AgNPs induce protective autophagy via a Ca2+/CaMKK beta/AMPK/mTOR pathway in vivo and in vitro. Therefore, public exposure to AgNPs should arouse concerns regarding environmental safety and human health.Li, LinLi, LuZhou, XuejiaoYu, YangLi, ...