Fasting increases but refeeding decreases the phosphorylation of AMPK and ACC in CaMKKbeta+/+ but not CaMKKbeta-/- mice. Under ad libitum feeding, the increased expression of sterol regulatory element binding protein-1c (SREBP-1c)-mediated lipogenic gene is concurrent with decreased ...
CaMKK betaMetformin, a widely prescribed antidiabetic drugPylaUnivRajkumarUnivPichavaramUnivPrahalathanUnivHansenUnivPaulUnivOsmanUnivIslamUnivSegarUnivLakshmanUnivBiochemical PharmacologyPyla R, Osman I, Pichavaram P, Hansen P, and Segar L (2014) Metformin exag- gerates phenylephrine-induced AMPK ...
In this study, we have established an in vitro model of SCI using neural cells from fetal rats to explore the relationship among them, and found that mechanical injury could promote the intracellular Ca2+ concentration, and the increased Ca2+ level activated autophagy through the CaMKK beta/AMPK...
CaMKK beta/AMPKPhotobiomodulation (PBM) could improve systemic blood glucose and insulin resistance in diet-induced diabetic mice. A few possible molecular mechanisms for the beneficial effects of PBM on diabetes have been proposed, but there is still an urgent need to explore the underlying ...
Cell contact activates AMP-Activated Protein Kinase (AMPK) through CaMKKbeta and the GTPase Rac1AMP-activated protein kinase (AMPK) has been identified as a target for cancer and metabolic diseases such as diabetes and obesity. Canonical activation of AMPK occurs as a result of energetic stress;...
CAMKK2 or AMPK overactivation is sufficient to induce dendritic spine loss. Conversely, inhibiting their activity protects hippocampal neu-rons against synaptotoxic effects of Ab42 oligomers in vitro and against the loss of dendritic spines observed in the human APP SWE,IND-expressing transgenic mouse...
In summary, this study is the first to report that AgNPs induce protective autophagy via a Ca2+/CaMKK beta/AMPK/mTOR pathway in vivo and in vitro. Therefore, public exposure to AgNPs should arouse concerns regarding environmental safety and human health.Li, LinLi, LuZhou, XuejiaoYu, YangLi, ...
Calcitriol reduces hepatic triglyceride accumulation and glucose output through Ca2+/CaMKK beta/AMPK activation under insulin resistant conditions in type 2 diabetes. Curr. Mol. Med. 2016, 16, 747-758. [CrossRef] [PubMed]
M3 muscarinic receptor activation reduces hepatocyte lipid accumulation via CaMKK beta/AMPK pathwayMuscarinic receptorAMPKNon-alcoholic fatty liver diseasePreviously, we reported that hepatic muscarinic receptors modulate both acute and chronic liver injury, however, the role of muscarinic receptors in fatty...