This is the first study evaluating the expression of CaMKIV in the brain of animals with DM, who presented lower expression of this protein in the hippocampus. In addition, it is the first time that CREB was evaluated in amygdala and hypothalamus of animals with DM, who presented a higher ...
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目的探讨癫痫性情感行为障碍与认知功能受损的神经生物学机制.方法在海马电点燃及发作间瘸样放电(IED)动物模型基础上,将64只Wistar大鼠随机分为IED,海马点燃,电极对照和正常对照4组(每组n=16).采用蛋白质免疫印迹法动态观测实验动物海马Ca^2+/CaM依赖性蛋白激酶IV(CaMKIV)与核转录因子cAMP反应元件结合蛋白(CREB)介导...
(CaMKIV)与核转录因子cAMP反应元件结合蛋白(CREB) 介导的核转录途径的变化规律.结果 电点燃后1 d,IED组与海马点燃组大鼠海马CaMKIV [2组 值分别为(2.97±0.88)和(3.06±0.92)]与CREB[(4.23±1.25)和(3.09±0.93)],磷酸化CREB[pCREB,(3.39±0.97)和(2.92±0.86)]及CREB结合蛋白[CBP,(2.82±0.82)...
Cole CJ, Josselyn SA (2008) Transcription regulation of memory: CREB, CaMKIV, Fos/Jun, CBP, and SRF. In: Sweatt JD, Byrne JH (eds) Learning and memory: a comprehensive reference, vol 4. Elsevier, Oxford, pp 547–566Cole C.J,Josselyn S.A.Transcription Regulation of Memory: CREB, Ca...
The transcription factor CREB is critical for several forms of experience-dependent plasticity in a range of species and is commonly activated in neurons by calcium/calmodulin-dependent protein kinase IV (CaMKIV). Surprisingly, little is known about the neural circuit adaptations caused by activation ...
NR2B-containing NMDA receptors promote neural progenitor cell proliferation through CaMKIV/CREB pathway. Biochem Biophys Res Commun. 2011; 411:667-672.Li Mei,Zhang Dong-qing,Wang Xiang-zhen,et al.NR2B-containing NMDA receptors promote neural progenitor cell proliferation through CaMKⅣ/CREB pathway....
CaMKIV limits metabolic damage through induction of hepatic autophagy by CREB in obese mice.doi:10.1530/JOE-19-0251Jiali LiuYue LiXiaoyan ZhouXi ZhangHao MengSanyuan LiuLei ZhangJuntao HeQian HeYan GengJ Endocrinol
Serotonin (5-HT)-induced CREB phosphorylation mediated by calcium/calmodulin-dependent protein kinase IV (CaMKIV) and extracellular signal-regulated protein kinase (ERK) in cultured cortical neurons of micedoi:10.1016/j.neures.2010.07.2102Jiro
Lithium effects on basal and stimulated CREB phosphorylation in SH-SY5Y cells: a bimodal action on CaMKIV and Erk1/2attention deficit hyperactivity disorderantisocial behaviourconduct disordergeneticsfamilylongitudinalIntroduction Antisocial behaviour is an important adverse outcome of ADHD. The aim of this...