Results We generated transgenic mice overexpressing alpha-CaMKII in the forebrain under the control of the alpha-CaMKII promoter. In contrast to alpha-CaMKII (+/-) heterozygous knockout mice, alpha-CaMKII overexpressing mice display an increase in anxiety-like behaviors in open field, elevated zero...
Molecular Brain BioMed Central Editorial Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia? 来自 Citeseer 喜欢 0 阅读量: 15 作者: PW Frankl,M Sakaguchi,M Arrudacarvalho 展开 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 Citeseer (全网免费下载) Citeseer ...
The SIRT1 action was associated with CaMKII alpha downregulation and deacetylation of histone H3 lysine 9 at the CaMKII alpha promoter. These results suggest that, by transcriptional repression of CaMKII alpha in central amygdala, SIRT1 functions to guard against the emotional pain vulnerability under...