The calyx of Held is a large glutamatergic synapse in the mammalian auditory brainstem. By using brain slice preparations, direct patch-clamp recordings can be made from the nerve terminal and its postsynaptic target (principal neurons of the medial nucleus of the trapezoid body). Over the last ...
The Calyx of Held is a giant nerve terminal that plays a crucial role in sound localization by mediating high-frequency excitatory input to principal cells in the medial nucleus of the trapezoid body (MNTB). It forms a highly reliable relay, capable of transferring presynaptic action potentials ...
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npg Acta Pharmacologica Sinica (2011) 32: 280–287 © 2011 CPS and SIMM All rights reserved 1671-4083/11 $32.00 www.nature.com/aps Review Synaptic vesicle recycling at the calyx of Held Lei XUE1, 2, Yan-ai MEI1, * 1Institutes of Brain Science, School of Life Sciences and State Key...
The calyx of Held is a giant glutamatergic synapse in the auditory system and displays multiple forms of short-term facilitation and depression. This study presents a detailed model of short-term plasticity at this synapse. The main components of the model are the presynaptic vesicle dynamics, whi...
The calyx of Held is a giant nerve terminal mediating high-frequency excitatory input to principal cells of the medial nucleus of the trapezoid body (MNTB). This synaptic connection is part of the lower auditory pathway and contributes to sound localization. Primary auditory neurons, receiving exci...