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品牌:MedChemExpress (MCE) 存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month. 生物活性:SM1-71 (compound 5) 是一种有效的 TAK1 抑制剂,Ki 为 160 nM,它还可以共价抑制 MKNK2、MAP2K1/2/3/4/6/7、GAK、AAK1、BMP2K, MAP3K7, MAPKA...
Empty CellPharyngeal pumping (pumps/min)Defecation interval (s)EMC/cycle (%) N2 241 ± 15 (20) 46 ± 01 (25) 97 ± 08 eat-3(tm1077) 96 ± 25 (20) N.D N.D calu-1(tm1783) 179 ± 22 (20) 82 ± 08 (51) 96 ± 08 itr-1(sy328)(gf) 247 ± 20 (20) 54 ± 07 (30...
Its action was inhibited by inhibitors of the NF-κB pathway, including-acetyl--cysteine, pyrrolidine dithiocarbamate, and a synthetic cell-permeable peptide containing the NF-κB nuclear localization signal sequence. Gel shift analysis showed that IL-1β activated NF-κB in Calu-3 cells, and ...
Calu-3 cells are a human airway epithelial cell line that exhibits secretory characteristics similar to airway gland epithelial cells when grown on Transwell membrane filters. QRT-PCR analysis revealed that Calu-3 cells express mRNA for multiple Toll receptor (TLR) subtypes including TLR1, TLR2, ...
In the present study, we identified the key effectors in the VIP signaling cascade in the human bronchial serous cell line Calu-3. Using immunocytochemistry and in situ proximity ligation assays, we found that VIP stimulation increased CFTR membrane localization by promoting its colocalization and ...
TNF-α induced leaks are shown to be mediated by the ERK signaling pathway. Conclusion: TNF-α induced a multiphasic transepithelial leak in Calu-3 cell layers that was shown to be ERK mediated, as well as involve changes in the TJ complex. The micronutrients, retinoic acid and calcitriol, ...
Apical adeno- sine regulates basolateral Ca2+-activated potassium channels in human airway Calu-3 epithelial cells. Am. J. Physiol. Cell Physiol. 294:C1443-C1453. doi:10.1152/ajpcell.00556.2007Wang D, Sun Y, Zhang W, Huang P. Apical adenosine regulates basolateral Ca2+-activated potassium ...
This molecular motor, a kinesin-3, transports early endosomes to the plus end of microtubules, in a process regulated by the small GTPase Rab5 and its effector, the phosphatidylinositol-3-OH kinase hVPS34. In vivo, KIF16B overexpression relocated early endosomes to the cell periphery and ...
T-cell derived mediators upregulate dimeric IgA transcytosis by the Calu-3 human lung epithelial cell lineA possible role of intercellular adhesion molecule 1 (ICAM-1, CD54) in transmembrane signaling was investigated in B cells from the Burkitt lymphoma cell line MTLM4. Cross-linking of membrane...