Calpains are calcium dependent, non-lysosomal neutral proteases that catalyze limited proteolysis (generally not more than one or two peptide bonds) of substrate proteins3. Calpains 1 and 2 are the major isoforms of calpain expressed in brain and, are ubiquitously and uniformly distributed in neuro...
Calpain 2 is a calcium-dependent intracellular protease that regulates adhesion turnover and disassembly through the targeting of specific substrates such as talin. Here, we describe a novel function for calpain 2 in the formation of invadopodia and in the invasive abilities of breast cancer cells ...
Calcium-dependent calpain proteases, in particular calpain-2, are more abundant in glioblastoma compared to normal brain and increased in patient-matched initial and recurrent glioblastomas. On the cellular level, pharmacological calpain inhibition increased the sensitivities of primary glioblastoma cells tow...
The two calpain subtypes are calpain-1 (μ-calpain) and calpain-2 (m-calpain) which differ in the calcium concentration required for their activation. Among different calpains, calpain-2 is particularly abundant in the central nervous system (CNS)6. In the AD brain there is an increased ...
In addition, overexpression of calpain-1 also induces transforming growth factor-β1/Smad signaling, elastin degradation, alkaline phosphatase activation, and total calcium content but reduces the expression of calcification inhibitors, osteopontin, and osteonectin, in cultured vascular smooth muscle cells ...
Targeting calcium signaling in cancer therapy 10.1016/j.apsb.2016.11.001 View PDF [27] L. Leloup, A. Wells Calpains as potential anti-cancer targets 10.1517/14728222.2011.553611 View in Scopus Google Scholar [28] J.C. Hewlett, J.A. Kropski, T.S. Blackwell ...
The cleavage of neuron-specific Cdk5 activator, p35, to p25, mediated by calpain and calcium, deregulates Cdk5 activity and promotes neurodegeneration. Fuzhisan (FZS), a Chinese herbal complex prescription that has been used for the treatment of AD for over 15years, is known to enhance the ...
Activation of Piezo1 by Yoda1 enhanced OGD/R-induced cell viability inhibition, apoptosis, increase intracellular calcium levels and enhanced calpain activity while GsMTx4 showed the opposite effects. The effects of Piezo1 activation on cell viability and apoptosis were reversed by PD151746.Piezo1 ...
mesodermformationandsegmentation. UsingtheTpromotertodriveCreexpressionintheprimitive streak,wehavecreatedbcateninlossandgainoffunction conditionsintrunkmesoderm.Weshowthatsegmentationcan occurineitherconditionhoweverthepositioningofthe abnormalsomitesalongtheAPaxisisdeterminedbythelevel ofWnt/bcateninsignaling.Wnt3a...
Tang, JianmingWang, TingtingYang, LianHong, LiElsevier ScienceCellular SignallingYang,Li,Cheng,etc.Electrical stimulation activates calpain 2 and subsequently upregulates collagens via the integrin β1/TGF-β1 signaling pathway.[J].2019,59.