if a gene had multiple instances of a protein domain, we first calculated the mean number of heterozygous rare (MAF < =0.5%) LOF variants observed (in
(intraclass correlation coefficient = 0.975, 95% CI 0.958 to 0.992) and there was a high level of agreement between the REs' estimates and the true values determined by food weighing; per the method of Bland and Altman the mean difference between the two types of estimates was 0.3 kcal (...