Although defects in intracellular calcium homeostasis are known to play a role in the pathogenesis of Parkinson’s disease (PD), the underlying molecular mechanisms remain unclear. Here, we show that loss of PTEN-induced kinase 1 (PINK1) and Parkin leads
N = 3; Two-way ANOVA with Tukey’s multiple comparisons test; *p = 0.0031, **p = 0.0025. Source data are provided as a Source Data file. Full size image Discussion Humans are exposed to most fungal pathogens, including A. fumigatus, through inhalation of fungal particles ...
We, thus, set out to study the role of microglia P2Y12–Gisignaling in regulating sleep. UsingTmem119-CreERT2mice for microglia-specific imaging and manipulation, we found that microglia P2Y12–Giactivation promoted sleep through a mechanism that depended on their intracellular Ca2+signaling. Micro...
In circulation, IGFBP3 is the predominant binding form in humans and rats. It was demonstrated that the half-life of IGF-1 in circulation can be extended by binding to IGFBP3 (6). Circulating IGF-1 levels can be strategically manipulated by dietary interventions to build peak bone mass and...
(paired two-tailedt-test; inf, ***P = 0.0001; ing, **PNREM = 0.0091, **Pwake = 0.0070, **PREM = 0.0056).h, Schematic for P2Y12 antagonist infusion.i,j, Confocal images (i) and quantification (j) of P2Y12 expression in Iba1+microglia in the prefrontal cortex (...
[7,8,9,10,11]. Although under homeostatic conditions the mouse microglial sensome broadly resembles that of humans [12,13,14], knowledge about the Ca2+dynamics of human microglia is scarce and so far restricted to cultured primary microglia (e.g., [15]) or cultured human induced ...
It is translated to the corresponding dose for humans and animals and administered using a 0.1 μM diluent. For seven days in a row, PBS or Ato was administered equally to each mouse’s back. Ultimately, the mice were put down on the eighth day by cervical dislocation under deep ...
Electrophysiological assessment of nociceptor activity and also the withdrawal reflex in humans have shown that such temporal summation is due to activity-dependent plasticity within the central nervous system (CNS) (Arendt-Nielsen et al., 1994; Koltzenburg and Handwerker, 1994). An important neural...
The calcium absorption enhancer of the present embodiment is used as, for example, a food additive added to a food composition ingested by humans and a feed additive added to a feed composition fed to domestic animals. Examples of foods include general foods, health foods, functional foods, and...
To reduce the complexity of the oligonucleotide mixture, five inosine bases were inserted at degenerated positions where no guidance could be obtained from the codon usage in humans. At nine positions, where two bases were possible, one of the bases was suggested with a likelihood exceeding 70% ...