Calcium release–activated calcium channel (CRAC)doi:10.1038/scibx.2013.1067Science-Business eXchange - Cell culture studies suggest agonizing CRAC could be useful for treating AD.Nature Publishing Group USScience-Business eXchangeNone
required for the cortisol-mediated rise in ([Ca2+]i). Particularly, the calcium release-activated calcium (CRAC) channel gating appears to be a key target for the rapid action of cortisol in the ([Ca2+]i) rise in trout hepatocytes. To test this further, we carried out in silico molecula...
As a proof of concept, we focused on calcium manipulation, as calcium is a key signaling pathway for many immune cells, including T and B lymphocytes, and several optogenetics strategies based on calcium release-activated channel (CRAC) have been proposed12,13,14,15,16. In T cells, calcium...
Finally, we will discuss how BK and other calcium-activated channels are modulated by novel ion channel modulators and describe some of the challenges associated with trying to develop compounds with sufficient efficacy, potency and selectivity to be of therapeutic benefit....
Large Conductance Calcium-Activated Potassium Channels The pore-forming α subunit of large conductance voltage- and Ca 2+ -activated K + channels (K Ca 1.1) is widely expressed throughout the nervous system. Four K Ca 1.1 subunits are required for channel activity, which contributes to th......
Calcium-dependent Signaling Cell Proliferation via Controlling KCa3.1 Regulates Vascular Smooth Muscle Calcium-activated Potassium Channel The Intermediate... dependent SignalingCell Proliferation via Controlling KCa3.1 Regulates Vascular Smooth MuscleCalcium-activated Potassium Channel The Intermediate ConductanceCell...
The type 3 small conductance calcium-activated potassium channel (SK3) is expressed in embryonic and adult denervated skeletal muscles where it contributes to hyperexcitability. This study aimed at determining the role of muscle activity... Morgana,Favero,De-Jian,... - 《Journal of Physiology》...
This gene encodes the calcium-activated potassium channel subunit alpha 1, KCa1.1 previously reported to be upregulated in prostate [37], breast [38] and other cancers [39, 40]. RT-qPCR confirmed upregulation of KCNMA1 mRNA in MPM cell lines compared to the normal immortalized mesothelial ...
(calcium-activated potassium channel of the SK type) that maintains firing regularity. (B) The Hodgkin-Huxley style equivalent electrical circuit for the model schematic in (A). The sodium and delayed rectifier potassium channels are modelled as stochastic, keeping all other ion channels ...
Calcium release activated channel regulator 2A (CRACR2A) regulates the activation of SOCE by interacting with Orai1 and STIM1 directly [23]. STIM1-modulator store-operated calcium entry associated regulatory factor (SARAF) has been demonstrated to activate Orai1 by its interaction with the C-...