In the present study, the potential role of ATPase plasma membrane Ca transporting 4 (PMCA4) in regulating EMT in gastric cancer (GC) was investigated. GC patients who underwent radical surgery were enrolled in this study. In vitro human GC cell lines MKN45 and NCI-N87 were used, and ...
Here we show that the plasma membrane calcium ATPase isoform 4 (PMCA4) regulates the calcium signal in cardiac fibroblasts, which is important in the regulation of cardiac hypertrophy. Genetic ablation and pharmacological inhibition of PMCA4 enhances the production of secreted frizzled related protein ...
Two of them operate in the plasma membrane, a Ca2+ ATPase (PMCA pump), and a Na+/Ca2+ exchanger (NCX), two inside the cell, in the endo(sarco)plasmic reticulum (ER) (a Ca2+ ATPase, the SERCA pump), and in the secretory pathway (the SPCA pump). The Ca2+-mediated signal ...
FITC,PE,APCamk1g(Calcium/calmodulin dependent protein kinase IG)??钙 FITC,PE,APIba-1(Ionized calcium bindingadaptor molecule-1)??离子钙接头蛋白抗原 abcamPMCA4/Calcium Pump PMCA4 ATPase,细胞膜钙ATP酶4抗体 1共1页 我要推广 优质信息推广广告 ...
Mouse monoclonal [JA9] to Calcium Pump PMCA4 ATPase| 基本信息更多信息 中文名称: 中文同义词: 英文名称:Mouse monoclonal [JA9] to Calcium Pump PMCA4 ATPase 英文同义词:Mouse monoclonal [JA9] to Calcium Pump PMCA4 ATPase CAS号: 分子式: ...
The altered PMCA4b expression led to enhanced Ca2+ clearance, suggesting that the protein plays an important role in the Ca2+ homeostasis of MCF-7 cells. Moreover, immunohistochemical analysis of normal breast tissue showed high PMCA4 expression in breast ductal epithelial cells, suggesting that ...
Pmca1+/− bladders had higher [Ca2+]i and force responses (Figure 86.2) to both KCl and carbachol (CCh) stimulation upon comparison to wild-type (WT) controls. In contrast, Pmca4−/− bladder responses to CCh were significantly suppressed (Figure 86.2), but not peak tension and [...
Thus, the PMCA pump is present in mammalian glial cells. These results also show that the amounts of PMCA1 and 4 isoforms in astrocytes are comparable to those found in neurons. In contrast, astrocytes contain smaller amounts of PMCA2. Furthermore, PMCA2 and PMCA4 underwent an evident ...
The second transporter involved in basolateral Ca 2 + extrusion is a P-type ATPase, a high-affinity Ca 2 + efflux pump PMCA1b, which is abundantly expressed in the intestine. Calcium is expelled through a channel-like opening formed by the transmembrane elements, and phosphorylation is ...
The plasma membrane Ca2+-ATPase (Ca2+ pump) (1) is a ubiquitously distributed P-type ATPase (2), consisting of a single polypeptide chain of about 134 kDa,... M Molinari,E Carafoli - Humana Press 被引量: 2发表: 0年 Novel structural role of the plasma membrane calcium pump(PMCA4) ...