Vascular calcification usually refers to a pathological process caused by the passive deposition of calcium phosphate in the blood vessel wall resulted from the imbalance of calcium and phosphorus metabolism. From: Analytical Biochemistry, 2023
This reduces phosphate uptake and generates phosphaturia (high urinary phosphate). A number of molecules are involved and include FGF-23, sFRP-4, MEPE, and PTH. 2, 33, 46, 102, 105 FGF-23, PTH and sFRP-4 are all reported to impact NPT2a activity. The effects of sFRP-4 are not...
Calcium/phosphate ratioPurpose Serum calcium/phosphate ratio (Ca/P) has been recently proposed as an additional tool to identify primary hyperparathyroidism (PHPT), especially in patients with subclinical presentation, with a proposed cut-off of 3.3 when both values are expressed in mg/dL. No ...
The PTH-Calcium Relation- ship during a range of infused PTH doses in the Parathyroidectomized Rat. Calcif Tissue Int. 1998; 62:457-461. PMID: 9541525Berdud I, Martin-Malo A, Almaden Y, Aljama P, Rodriguez M and Felsenfeld AJ. The PTH-calcium relationship during a range of infused ...
R. Calcium phosphate-induced renal epithelial injury and stone formation: involvement of reactive oxygen species. Kidney Int. 64, 1283–1291 (2003). Article CAS PubMed Google Scholar Colditz, G. A. The Nurses’ Health Study: a cohort of US women followed since 1976. J. Am. Med. Women...
The regulatory mechanism of calcium homeostasis is complex and mainly involves hormones [parathyroid hormone (PTH), vitamin D, etc.] and calcium channel proteins. PTH in the kidney, on the one hand, increases renal calcium reabsorption and phosphate excretion, and on the other hand it increases ...
The PTH dosage that produced a normal serum calcium (10.09 +/- 0.10 mg/dl) and phosphorus (6.90 +/- 0.18 mg/dl) was 0.022 microg/100 g/hour. The relationship between increasing doses of PTH and both serum calcium and phosphorus was curvilinear and the calcium-phosphorus product was ...
Schwarz P, Madsen JC, Rasmussen AQ, Transbol I, Brown EM: Evidence for a role of intracellular stored parathyroid hormone in producing hys- teresis of the PTH-calcium relationship in normal humans. Clin Endo- crinol (Oxf) 1998;48:725-732....
Phosphate moves in and out of bone, as bone is deposited and resorbed. P i is lost in the stools as well as excreted by the kidney. Hormonal regulation of body P i homeostasis is similar to regulation of blood calcium levels, in that it involves PTH and 1,25(OH) 2 D 3 . ...
However, renal PCT CaSR expression is suppressed following acute PTH infusion and dietary phosphate loading (Riccardi et al., 2000) and upregulated by calcitriol (Canaff and Hendy, 2002), suggesting an independent, local negative feedback loop for phosphate regulation and calcium movement in this...