Although numerous models have been proposed for its mechanism of action, none have been definitive. An assay dependent on GEF activity was developed using highly purified eukaryotic initiation factor 2 (eIF-2) and GEF from Ehrlich cells. GEF was considered in terms of an enzyme whose catalytic ...
Calcium and iron absorption: mechanism of action and nutritional importance. Eur J Clin Nutr 1992;46:317-27.Hallberg L,Rossander-Hulten L,Brune M,Glee... Hallberg,L.,Rossander-Hutten - 《Journal of the American Dietetic Association》 被引量: 0发表: 1992年 Tri-part calcium fortified composit...
As the exact mechanism involved in these cardiovascular effects of the two melanocortins is as yet not known, we undertook a series of experiments to ... PV Bergen,W Vleeming,BGVV Heijst,... - Naunyn-Schmiedeberg's Archives of Pharmacology 被引量: 14发表: 1998年 investigation of the spec...
The mechanism of action of these drugs appears to involve partly the inhibition of gastric acid secretion and neutralization of secreted acid. We conclude ... Y Tsukimi,S Okabe - 《Journal of Gastroenterology & Hepatology》 被引量: 29发表: 2010年 Omeprazole in elderly duodenal ulcer patients: ...
Considering the importance of calcium (Ca2+) in regulating sperm capacitation, hyperactivation and acrosome reaction, little is known about the molecular mechanism of action of this ion in this process. In the present study, assessment of the molecular mechanism from the perspective of energy metabo...
Mechanism of action Dna synthesis effects Q13-1 MTX competitively and reversibly binds to dihydrofolate reductase within 1 hour, with an affinity greater than that of folic acid. This prevents the conversion of dihydrofolate to tetrahydrofolate. Tetrahydrofolate is a necessary co-factor in the product...
CRESTOR decreases synthesis ofcholesteroland possibly other biologically active substances derived from cholesterol; therefore, CRESTOR may cause fetal harm when administered to pregnant patients based on the mechanism of action [seeCLINICAL PHARMACOLOGY]. In addition, treatment ofhyperlipidemiais not generally...
Here we report the cloning and functional expression of a h... Wissenbach,U. - 《Journal of Biological Chemistry》 被引量: 423发表: 2001年 The role of nutrition in preventing prostate cancer: a review of the proposed mechanism of action of various dietary substances Background: Dietary ...
Calcium influx through the N-methyl-d-aspartate (NMDA)-type glutamate receptor and activation of calcium/calmodulin-dependent kinase II (CaMKII) are critical events in certain forms of synaptic plasticity. We have previously shown that autophosphorylation of CaMKII induces high-affinity binding to the...
The mechanism through which synaptic activity leads to increases in the intranuclear calcium concentration involves stimulation of synaptic NMDA receptors, generation of backpropagating action potentials and the opening of voltage-gated calcium channels. Nuclear calcium transients may also be initiated or enh...