The pharmacological properties of (I) on i.v. administration differ from those of Ca gluconate and glucose. The complexed Ca has a strophanthin-like but completely non-toxic action, while the unstable glucose acts in the blood as an oxygen carrier.TIMMERMANS,FRANZ DONATUS,PROF. DR. MED. ...
Acute symptomatic hypocalcemia requires therapy with intravenous calcium. This can be given as 10 to 20 mL ofcalcium gluconate(90 mg of Ca++per 10-mL ampule) infused at no more than 2 mL/min. This should be repeated as needed to keep the patient free of symptoms. In hypocalcemia associated...
Parathormone is known to increase resorption of bone by increasing both the numbers and the activity of osteoclasts: but this action is possibly pharmacological or pathological rather than physiological–it occursonly if plasma ionised calcium levels are severely reduced. In physiological amounts parat...
Goodman and Gilman’s The pharmacological basis of therapeutics. 10th ed. New York: McGraw-Hill, 2001: 1924–2023 Pearigen PD. Calcium channel blocker poisoning. In: Haddad LM, Shannon MW, Winchester JF, editors. Clinical management of poisoning and drug overdose. 3rd ed. Philadelphia:, WB S...
Because of their similarity of end-organ affinity, pharmacological action, and target patients, beta-blockers are the most common confounders. Compared to CCBs, beta-blockers are less likely to cause hyperglycemia in adult patients.[36]
Investigators weren’t blind to the pharmacological interventions during the analysis. Mechanical stimulation measurements were excluded when the membrane was injured during the pipette-membrane engagement, indicated by responses to the voltage test-pulses. Besides the pre-mature intracellular access, patch-...
For action potential recordings and for glutamatergic currents recordings, pipettes (6–8 MΩ) were filled with (in mM): 139 K-gluconate, 10 HEPES, 0.1 EGTA acid, 1 MgCl2, 2 MgATP, 0.5 Na-GTP, 5 Na2-phospocreatine, 2.5 Na-pyruvate, 2 malate, pH 7.3 with KOH (295 mOsm adjusted ...
Our results provide insights into the pharmacological resistance properties of CaV2.3, the asynchronous functional roles of the VSDs, the mechanism by which the pre-W-helix regulates the CSI, and the OSI process modulated by the negatively charged domain on S6II (S6IINCD). Results and ...
TRANSLATIONAL OUTLOOK: Despite decades of electrophysiology research, SAN-initiated arrhythmias are among the most recalcitrant to pharmacological therapy, and SSS often requires electronic pacemaker insertion. One reason for these therapeutic shortcomings may be that important molecular and cell discoveries of...
The mechanism of action of pharmacological therapies for calcium channel blockers and beta blockers and poisoning on cardiac myocytes.45 5′ AMP, 5′ adenosine monophosphate; ATP, adenosine triphosphate; β1, β1-receptor; β-Ag, β-agonist (catecholamine); cAMP, cyclic adenosine mono...