a tropolone, a coumarin, or an antioxidant containing an aromatic group and with the further proviso that if I 3 is 0, and either I 1 and I 2 is 0 or 1 and if R 1 and/or R 2 represent F in the para position, Z cannot N or C; and are useful as calcium channel blockers. ...
钙通道阻滞剂 (Calcium channel blockers),简称 CCB,是一类阻断 Ca2+ 内流的钙 (离子) 通道拮抗剂,主要阻断心肌和血管平滑肌细胞 (SMCs) 上的 L-型钙通道。CCB 通过阻止钙离子进入血管平滑肌,导致肌肉松弛和血管舒张,并导致血管阻力降低,从而降低动脉血压。 钙离子通道 Ca2+ 是一种普遍存在的细胞内信使,而钙通...
Calcium-channel blockers for hyperten- sion--uncertainty continues. N Engl J Med 1998; 338: 679-681.Cutler JA. Calcium-channel blockers ... Cutler,A Jeffrey - 《New England Journal of Medicine》 被引量: 225发表: 1998年 Calcium channel blockers in heart failure The rationale for the use...
CALCIUM CHANNEL BLOCKERS 专利名称：CALCIUM CHANNEL BLOCKERS 发明人：SNUTCH, TERRANCE, PRESTON,ZAMPONI, GERALD, WERNER 申请号：CA9900612 申请日：19990630 公开号：WO0001375A3 公开日：20000831 专利内容由知识产权出版社提供 摘要：Compounds of formula (1) wherein m is 0, 1 or 2; wherein when m ...
网络钙通道阻滞剂;钙通道阻滞药;钙通道拮抗剂 网络释义
Calcium-channel blockers are a distinct group of compounds that interfere with the normal transmembrane flux of extracellular calcium ions on which vascular tissue depends for contraction or impulse generation. The drugs reduce the contractile activity of the heart, and promote coronary and systemic vas...
Recent reports suggest that calcium-channel blockers may be harmful in patients with diabetes and hypertension. We previously reported that antihypertensiv... J Tuomilehto,D Rastenyte,WH Birkenhäger,... - 《N Engl J Med》 被引量: 2934发表: 1999年 Predicting Cardiovascular Risk Using Convent...
These agents are often not sufficient if hypertension is severe, in which case, calcium-channel blockers (nifedipine and verapamil) typically are used as first-choice antihypertensives. Oral contraceptive pill preparations may be used in adult women with mild forms of the disease to ameliorate some...
channel英/'tʃæn(ə)l/美/'tʃænl/ 释义n.电视台;频道;途径;方式;通道;水渠;航道;海峡;河床;信道 例句What channel do you like to watch best? 你最喜欢看哪一个频道的节目? blocker/'blɑkɚ/ 释义n.阻挡者;堵塞物;(排球)拦网(或封网)队员;阻挡投球的队员 ...
Fisher, S. Desideri, S.A. Grossman, R.L. Wahl, D. Schiff Timed sequential therapy of the selective T-type calcium channel blocker mibefradil and temozolomide in patients with recurrent high-grade gliomas Neuro-Oncol., 19 (6) (2017), pp. 845-852, 10.1093/neuonc/nox020 View in Scopus...