when calcium channel blockers are taken beyond the appropriate recommended dosage, they can have untoward toxicities with a wide range of complications that can even be fatal. This activity discusses their use to treat a wide array of clinical ...
Noun1.calcium-channel blocker- any of a class of drugs that block the flow of the electrolyte calcium (either in nerve cell conduction or smooth muscle contraction of the heart); has been used in the treatment of angina or arrhythmia or hypertension or migraine ...
In the current study, we aimed to contribute to drug discovery and to determine the interaction of some calcium channel blockers (CCBs) with PON1. For this purpose, first, the PON1 enzyme was purified from fresh human serum by using different chromatographic techniques. Then, the various ...
Calcium channel blockers are drugs used to manage angina pectoris, hypertension, and other heart-related conditions. The mode of action of these drugs is to inhibit the flow of calcium into the heart's cells; these medications can help relax and open up the arteries, improving blood flow and...
channel blockers in routine clinical practice. for reasons of statistical power and result interpretation, we elected a priori not to study the cyp3a4 inhibitor erythromycin, because in ontario this drug was prescribed less than once for every 20 clarithromycin prescriptions. 3 the date of the ...
attractive target for drug development. Although several compounds are under preclinical investigation as T-type channel blockers, no clinical data exist with which to gauge their clinical utility against neuropathic pain (Hildebrand, M. E. and Snutch, T. P., 2006)....
Currently, approved calcium-channel blockers (CCBs) bind to L-type calcium channels on vascular smooth muscle, cardiac myocytes, and cardiac nodal tissue (sinoatrial and atrioventricular nodes). These channels regulate the influx of calcium into cells. In vascular smooth muscle and cardiac myocytes,...
Objective.— To assess whether calcium channel blocker use increases the risk of cancer overall and of specific cancers. Design.— Case-control drug surveillance study based on data collected from 1983 to 1996. Setting.— Hospitals in Baltimore, Md, New York, NY, and Philadelphia, Pa. Patients...
Effect of a calcium-channel blocker (verapamil) on the morphology, cytoskeleton and collagenase activity of human skin fibroblastsCytosolic calciumHuman fibroblastCollagenaseActinThe effects of verapamil modulating collagen biosynthesis have prompted us to study the role of this drug in cultured fibroblasts....
Calcium channel blockers may improve treatment for pancreatic cancer patients receiving gemcitabine-based chemotherapy, according to recent findings published in the Proceedings of the National Academy of Sciences.