Modulation of the cardiac action potential by calcium-activated inward currents: Trevor Powell, University Laboratory of Physiology, Parks Road, Oxford OX1 3PTdoi:10.1016/0022-2828(88)90261-1NoneELSEVIERJournal of Molecular & Cellular Cardiology...
1. Noradrenaline biphasically affects the duration of the action potential (AP) of guinea-pig cardiac ventricular muscle. Low concentrations (10-7M) prolong the AP duration, while high (10-5M) concentrations shorten it after an initial prolongation. The extent of the AP-prolonging effect is more...
During the cardiac action potential, it is the rise in the level of cytoplasmic calcium as well as the sensitivity of several calcium-sensitive proteins to that released calcium that determines the force of myocardial contraction. Both calcium entry and sensitivity are significantly reduced in heart ...
Cardiac Action Potential Model with Spatial Subcellular Calcium Cycling and Physiological Transmembrane Currentspregnancypre-eclampsiahypertensionblood pressure variabilitysegmented Poincare plot analysiscardiovascular regulationNot Availabledoi:10.1016/j.bpj.2009.12.3898Sato, Daisuke...
Effects of the calcium entry blocker bepridil on repolarizing and pacemaker currents in sheep cardiac Purkinje fibres. (1) Effects of bepridil (0.3–100 μmol/l) on transmembrane currents which are active during the repolarization of the cardiac action potential were studie... F Berger,U Borchar...
Action potentials and voltage clamp-induced ionic currents were recorded in acutely isolated neonatal rabbit cardiac myocytes using the whole-cell voltage clamp technique. Time- and voltage-dependent Cacurrents in neonatal myocytes were elicited by depolarizations from a holding potential of —80 mV to...
Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ Res 2003; 93: 32–9. CAS PubMed Google Scholar Reppel M, Pillekamp F, Brockmeier K, Matzkies M, Bekcioglu A, Lipke T, et al. The electrocardiogram of human embryonic stem ...
We have used the two-microelectrode voltage-clamp technique to investigate the components of membrane current that contribute to the formation of the early part of the plateau phase of the action potential of calf cardiac Purkinje fibers. 3,4-Diaminopyridine (50 microM) reduced the net transient ...
Volume 23, Supplement 4, June 1991, Pages S32 Program and Abstracts of the 8th G.R.R.C Meeting About ScienceDirect Contact and support Information for advertisers Terms and conditions Privacy policy Copyright © 2014 Elsevier B.V. except certain content provided by third parties. Scienc...
During aging, the magnitude of L-type Ca ++ channel current (I Ca,L ) is significantly increased in parallel with the enlargement of cardiac myocytes, resulting in unaltered I Ca,L density. Since the inactivation of I Ca,L is slowed and the action potential duration is prolonged, the net...