action potential durationalternansarrhythmiaatriacalciumexcitation‐contraction couplingK+ currentKey points: Cardiac alternans refers to a beat-to-beat alternation in contraction, action potential (AP) morphology and Ca2+ transient (CaT) amplitude, and represents a risk factor for cardiac arrhythmia, ...
Cardiac Action Potential Model with Spatial Subcellular Calcium Cycling and Physiological Transmembrane Currentspregnancypre-eclampsiahypertensionblood pressure variabilitysegmented Poincare plot analysiscardiovascular regulationNot Availabledoi:10.1016/j.bpj.2009.12.3898Sato, Daisuke...
Action potentials and voltage clamp-induced ionic currents were recorded in acutely isolated neonatal rabbit cardiac myocytes using the whole-cell voltage clamp technique. Time- and voltage-dependent Cacurrents in neonatal myocytes were elicited by depolarizations from a holding potential of —80 mV to...
This increase has been shown to be the consequence of a prolongation of the cardiac action potential duration, mainly via an increase of Cavα1C subunit expression and current. Interestingly, the mutant p.I1166T has been reported in patients with TS and in a patient with LQT8 (Table 1) ...
The effect of intracellular cyclic nucleotides and calcium on the action potential and acetylcholine response of isolated cardiac cells . Pflügers Arch. , 392 , 307 – 314 .Trautwein, W. , Taniguchi, J. & Noma, A. ( 1982 ). The effect of intracellular cyclic nucleotides and calcium on ...
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The plateau of the cardiac action potential, contraction of muscle cells, generation of pace maker potentials, the release of hormones and neurotransmitters, sensory functions, and gene expression are all mediated by fine-tuned calcium entry through voltage-dependent calcium channels [27,49,96,120]....
Calcium channel types in cardiac myocytes: modulation by dihydropyridines and beta-adrenergic stimulation. J Cardiovasc Pharmacol 8 Suppl 9: S11–21, 1986 PubMed CAS Google Scholar Hille B. Ionic channels of excitable membranes. Sunderland, Mass.: Sinauer Associates, 1992 Google Scholar Hille B....
8. Carlo Napolitano, et al. Phenotypical manifestations of mutations in the genes encoding subunits of the cardiac voltage-dependent L-type calcium channel. Circ Res. 2011 Mar 4;108(5):607-18. 9. Annette C Dolphin. Voltage-gated calcium channels: their discovery, function and importance as ...
What causes the rapid depolarization phase seen in the action potential of cardiac myocytes? a. the movement of sodium into the cell b. the movement of sodium out of the cell c. the movement of calcium into the cell d. the movement of calcium out of the c ...