Modulation of the cardiac action potential by calcium-activated inward currents: Trevor Powell, University Laboratory of Physiology, Parks Road, Oxford OX1 3PTdoi:10.1016/0022-2828(88)90261-1NoneELSEVIERJournal of Molecular & Cellular Cardiology...
1. Noradrenaline biphasically affects the duration of the action potential (AP) of guinea-pig cardiac ventricular muscle. Low concentrations (10-7M) prolong the AP duration, while high (10-5M) concentrations shorten it after an initial prolongation. The extent of the AP-prolonging effect is more...
First, an action potential depolarizes the sarcolemma. Second, this depolarization releases Ca 2+ from the subsarcolemmal cisternae of the sarcoplasmic reticulum (SR), allows entry of calcium from outside the sarcolemma, or both. Third, Ca 2+ diffuses to troponin-C on the thin filaments, and...
Cardiac Action Potential Model with Spatial Subcellular Calcium Cycling and Physiological Transmembrane Currentspregnancypre-eclampsiahypertensionblood pressure variabilitysegmented Poincare plot analysiscardiovascular regulationNot Availabledoi:10.1016/j.bpj.2009.12.3898Sato, Daisuke...
Calcium (Ca(2+)) is a critical regulator of cardiac myocyte function. Principally, Ca(2+) is the link between the electrical signals that pervade the heart and contraction of the myocytes to propel blood. In addition, Ca(2+) controls numerous other myocyte activities, including gene transcript...
Action potentials and voltage clamp-induced ionic currents were recorded in acutely isolated neonatal rabbit cardiac myocytes using the whole-cell voltage clamp technique. Time- and voltage-dependent Cacurrents in neonatal myocytes were elicited by depolarizations from a holding potential of —80 mV to...
Effects of the calcium entry blocker bepridil on repolarizing and pacemaker currents in sheep cardiac Purkinje fibres (1) Effects of bepridil (0.3鈥 100 mol/l) on transmembrane currents which are active during the repolarization of the cardiac action potential were studied ... F Berger,UB Hafner...
Eight weeks after surgery, single cardiac ventricular myocytes were isolated from the hearts of the rats. The APs and ICa-L were recorded using the whole-cell patch clamp technique. Results. The action potential duration (APD) of the TAC group was prolonged compared with the control group and...
Testosterone and the cardiac action potential As SR Ca2+ release and contraction are initiated by the cardiac AP, some investigators have explored the influ- ence of testosterone on AP properties (Table 2). Chronic exposure to testosterone itself has no effect on resting membrane potential (RMP),...
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