EDITOR—The study by Porthouse et al had two major design flaws.1 Firstly, the dose of vitamin D (800 IU per day) is subphysiological and therefore subtherapeutic. Secondly, their use of "self report" as a measure of compliance is unreliable.The dose of vitamin D at 800 IU daily was ...
It can also be found in food and supplements. This is one of the four fat-soluble vitamins. That means that it's stored in the body's fatty tissue and can build up to toxic levels with excessive consumption. The current thinking, however, is that the potential toxicity of vitamin D ...
It can also be found in food and supplements. This is one of the four fat-soluble vitamins. That means that it's stored in the body's fatty tissue and can build up to toxic levels with excessive consumption. The current thinking, however, is that the potential toxicity of vitamin D ...
A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med. 2012;367(1):40-49. doi:10.1056/NEJMoa1109617PubMedGoogle ScholarCrossref 16. Avenell A, Mak JC, O’Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and...
Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA. 2010;303(18):1815-1822.ArticlePubMedGoogle ScholarCrossref 35. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-281.PubMedGoogle ScholarCrossref 36. Moyer VA;...
EDITOR—The study by Porthouse et al had two major design flaws.1 Firstly, the dose of vitamin D (800 IU per day) is subphysiological and therefore subtherapeutic. Secondly, their use of "self report" as a measure of compliance is unreliable.The dose of vitamin D at 800 IU daily was ...
Excerpt The charge to the committee (Institute of Medicine Committee to Review Dietary Reference Intakes for Vitamin D and Calcium) was to assess current relevant data and update, as appropriate, the DRIs (Dietary Reference Intakes) for vitamin D and calcium. The review was to include consideratio...
Calcium supplements with or without vitamin D and risk of cardiovascular events: Reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ. (2011) 342:d2040. 10.1136/bmj.d2040 Ananth CV, Keyes KM, Wapner RJ. Pre-eclampsia rates in the United States. 1980-...
revealed a striking overexpression of these genes in the kidney cortex; the GENE2FUNC tool demonstrated enrichment for gene ontologies associated with transmembrane ion transport, renal function, and calcium homeostasis, including response to vitamin D (Supplementary Figs.2–3and Supplementary Table5)20...
This study was a population-based RCT that used an intervention with a relatively high dose of vitamin D3 that increased mean serum 25(OH)D level, had low participant drop out, measured 25(OH)D level at baseline and annually on all participants, had on-site monitoring every 6 months, ...