Provan SA, Olsen IC, Austad C, Haugeberg G, Kvien TK, Uhlig T. Calcium supplementation and inflammation increase mortality in rheumatoid arthritis: A 15-year cohort study in 609 patients from the Oslo Rheumatoid Arthritis Register. Semin Arthritis Rheum. 2017;46:411-7....
Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis Abstract Increased extracellular Ca2+concentrations ([Ca2+]ex) trigger activation of the NLRP3 inflammasome in monocytes through calcium-sensing receptor (CaSR). To prevent extra...
The untreated arthritic rats had visible articular inflammation on day 30, and the average hindpaw diameter was between 8.1 and 8.9 mm. In control animals hindpaw diameter was between 5.3 and 5.6 mm. Treatment with CsA prevented the development of arthritis (paw diameter Discussion Experimental ...
The recognition of tissue deposits of crystalline material in a variety of organs, including the kidney, predated the association of crystals and arthritic disease. Because of this, the pathophysiology of crystal formation and its resultant inflammation is based in part on studies of renal stones. ...
Reginato AJ, Kurnik B: Calcium oxalate and other crystals associated with kidney disease and arthritis. Semin Arthritis Rheum 18:198-224, 1989Reginato AJ, Kurnik B. 1989. Calcium oxalate and other crystals associated with kidney diseases and arthritis. Semin Arthritis Rheu 18(3): 198-224....
High doses of niacin can cause dangerous liver inflammation, peptic ulcers, and skin rashes. "Niacin flushing" is a side effect that causes redness, itching, and burning and can occur within 10 to 15 minutes after taking it and can last up to one hour. Research has shown that there are...
Articular calcium-containing crystals cause calcium pyrophosphate dihydrate (CPPD) deposition disease, basic calcium phosphate (BCP)-associated syndromes, and calcium oxalate arthritis. During the past year, important contributions have been made to our understanding of CPPD- and BCP-related syndromes. Cli...
The fos-related antigen 1-JUNB/activator protein 1 transcription complex, a downstream target of signal transducer and activator of transcription 3, induces T helper 17 differentiation and promotes experimental autoimmune arthritis. Front Immunol. 2017;8(DEC):1793. Karakaslar EO, Katiyar N, Hasham ...
Arthritis Rheum. 56, 3138–3148 (2007) Article CAS Google Scholar Chae, J. J. et al. Gain-of-function pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice. Immunity 34, 755–768 (2011) Article CAS Google Scholar Menkin, V. ...
Very rare reactions of eye inflammation including iritis and uveitis have been reported. Osteonecrosis of the jaw has been reported very rarely (seePRECAUTIONS,General). Calcium Calcium carbonate may cause gastrointestinal adverse effects such as constipation, flatulence, nausea, abdominal pain, and bloat...