(2007) The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans. Int J Parasitol 37: 1577-88.Guest, M. et al. The calcium-activated potassium channel, SLO-1, is required for the action ...
3.2.1.3 Sodium-dependent potassium channel SLO2 and possible physiological roles The high-conductance potassium channels that are sensitive to intracellular sodium, also called Na+-activated potassium channels (KNa or SLO2) have been described first in cardiomyocytes and then...
A component of calcium-activated potassium channels encoded by the Drosophila slo locus Calcium-activated potassium channels mediate many biologically important functions in electrically excitable cells. Despite recent progress in the molecula... N Atkinson,G Robertson,B Ganetzky - 《Science》 被引量: ...
Large-conductance calcium and voltage-activated potassium channels, termed SLO-1 (or BK), are pivotal players in the regulation of cell excitability across the animal phyla. Furthermore, emerging evidence indicates that these channels are key mediators of a number of neuroactive drugs, including the...
A cytoplasmic domain of either the channel or an accessory subunit is thought to plug the open pore to inactivate the channel via a ‘ball-and-chain’ mechanism3,4,5,6,7. Here we use cryo-electron microscopy to identify the molecular gating mechanism in calcium-activated potassium channels ...
Tissue-specific expression of a Drosophila calcium-activated potassium channel The Drosophila slowpoke (slo) gene encodes a subunit of a CAK channel homologous to the vertebrate BK channel. We have examined slo expression throughout d... MN Becker,R Brenner,NS Atkinson - 《Journal of Neuroscience...
(NE). Here we demonstrate the presence of functional large-conductance, calcium-activated potassium channels (BK channels) on the NE of rodent hippocampal neurons. Functionally, blockade of nuclear BK channels (nBK channels) induces NE-derived Ca2+release, nucleoplasmic Ca2+elevation and cyclic AMP...
A component of calcium-activated potassium channels encoded by the Drosophila slo locus. Science 1991; 253: 551–5. CAS PubMed Google Scholar Knaus HG, Garcia-Calvo M, Kaczorowski GJ, Garcia ML . Subunit composition of the high conductance calcium-activated potassium channel from smooth muscle,...
Calcium-Dependent Potassium Channels Two types of calcium-activated potassium channels have been described in various systems: mitoBKCa (big conductance potassium channel) and mitoIKCa (intermediate conductance channel). MitoBKCa (KCa1.1), displaying a conductance of 100–300 pS, has been observed by...
The calcium-activated potassium channel family The calcium-activated channels exhibit the characteristics of a transducer between the ubiquitous cytoplasmic calcium signals and the electrical variations of the cell membrane. Among the diverse types of channels that exhibit these prop- erties, the calcium...