CrCl(mL/min)=(Pr−V∗10∗(SCr2−SCr1)ΔTime)∗100(SCrx)∗1440Pr=SCrproductionrate(mg/day)Pr(men)=BodyWeight∗(29.3−(0.203∗Age))Pr(women)=BodyWeight∗(25.3−(0.175∗Age))SCr1=LessrecentSCr(mg/dL)SCr2=MorerecentSCr(mg/dL)SCrx=SCr2(ifSCrisincreasing)orSCr1...
3.23∗(CrCl/40)0.693.23∗(CrCl/40)0.69Bauer Method 7CLvanco is estimated using a linear relationship to creatinine clearance while normalizing to total body weight:CLvanco=(0.695∗CrCl/TotalBW+0.05)∗TotalBW∗0.06CLvanco=(0.695∗CrCl/TotalBW+0.05)∗TotalBW∗0.06Matzke...
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the literature, with Vd being described between 0.5 and 1 L/kg.4There is some evidence that patients with reduced creatinine clearance (CrCl < 60 mL/min) have a larger Vd of 0.83 L/kg, whereas patients with preserved renal function (CrCl ≥ 60 mL/min) have a smaller Vd of 0.57 L/...
between prodrug and active moiety is one of the reasons for the current debate regarding optimal CMS dosage regimens. It also underlies the difficulty in dosing CMS in patients with normal renal function (CrCL ≥ 70 mL/min/1.73 m2) who may have low colistin plasma concentrations as a result....
3.23∗(CrCl/40)0.693.23∗(CrCl/40)0.69Bauer Method 7CLvanco is estimated using a linear relationship to creatinine clearance while normalizing to total body weight:CLvanco=(0.695∗CrCl/TotalBW+0.05)∗TotalBW∗0.06CLvanco=(0.695∗CrCl/TotalBW+0.05)∗TotalBW∗0.06Matzke...