3.23∗(CrCl/40)0.693.23∗(CrCl/40)0.69Bauer Method 7CLvanco is estimated using a linear relationship to creatinine clearance while normalizing to total body weight:CLvanco=(0.695∗CrCl/TotalBW+0.05)∗TotalBW∗0.06CLvanco=(0.695∗CrCl/TotalBW+0.05)∗TotalBW∗0.06Matzke...
While several population estimates exist, this calculator uses the Creighton equation 1 to estimate Kel for a given CrCl using the Cockcroft-Gault method:2 Kel=0.00083∗(CrCl)+0.0044Kel=0.00083∗(CrCl)+0.0044 Importantly, this method relies on an accurate creatinine clearance; therefore, ...
2 This is particularly a concern for patients with normal renal function (CrCL ≥ 70 mL/min/1.73 m2) who may have lower colistin plasma concentrations with the maximum daily dosage recommended in current product labeling (300 mg CBA per day or about 5 mg/kg/day).1,2...
3.23∗(CrCl/40)0.693.23∗(CrCl/40)0.69Bauer Method 7CLvanco is estimated using a linear relationship to creatinine clearance while normalizing to total body weight:CLvanco=(0.695∗CrCl/TotalBW+0.05)∗TotalBW∗0.06CLvanco=(0.695∗CrCl/TotalBW+0.05)∗TotalBW∗0.06Matzke...
the literature, with Vd being described between 0.5 and 1 L/kg.4There is some evidence that patients with reduced creatinine clearance (CrCl < 60 mL/min) have a larger Vd of 0.83 L/kg, whereas patients with preserved renal function (CrCl ≥ 60 mL/min) have a smaller Vd of 0.57 L/...