and Krasikova, A.V., Cajal bodies and histone locus bodies: molecular structure and function, Ontogenez , 2014, vol. 45, no. 6 pp. 363–5.Khodyuchenko TA, Krasikova AV. Cajal bodies and histone locus bodies: Molecular composition and func- tion. Russian Journal Of Developmental Biology...
The Cajal body is an example of a conserved nuclear compartment that has been linked to molecular disease. Recent studies have shown Cajal bodies to be surprisingly mobile and offer clues about their function in the cell.关键词: bodies
Cajal bodies, or CBs, are universal entities found in both the nucleolus and nucleoplasm of most living cells. Their function relates to RNA metabolism, including transcription, splicing, stable RNA modification, small RNA biogenesis, gene silencing, nonsense-mediated decay and telomere maintenance. ...
Cajal bodies (CBs) are nuclear organelles that are usually identified by the marker protein p80-coilin. Because no orthologue of coilin is known in Drosophila melanogaster, we identified D. melanogaster CBs using probes for other components that are relatively diagnostic for CBs in vertebrate cells....
The nucleolus and Cajal bodies (CBs) are prominent interacting subnuclear domains involved in a number of crucial aspects of cell function. Certain viruses interact with these compartments but the functions of such interactions are largely uncharacterized. Here, we show that the ability of the ground...
RNAs that are highly similar in structure and function to snoRNAs are the so-called small Cajal body-associated RNAs (scaRNAs), which assemble in Cajal bodies to modify spliceosomal small nuclear (sn)RNAs19,20,21, or to elongate telomeres (the telomerase RNA is a scaRNA). Antisense elements...
Coilin protein scaffolds Cajal bodies (CBs)—subnuclear compartments enriched in small nuclear RNAs (snRNAs)—and promotes efficient spliceosomal snRNP assembly. The molecular function of coilin, which is intrinsically disordered with no defined motifs, is poorly understood. We use UV crosslinking and ...
Cajal bodies (CBs) are evolutionarily conserved nuclear organelles that contain many factors involved in the transcription and processing of RNA. It has been suggested that macromolecular complexes preassemble or undergo maturation within CBs before they function elsewhere in the nucleus. Most such models...
Small-molecule flunarizine increases SMN protein in nuclear Cajal bodies and motor function in a mouse model of spinal muscular atrophy Matthieu Dos Santos, Suzie Lefebvre Scientific Reports8, Article number:2075(2018)Cite this article 3484Accesses...
Spliceosomal small nuclear ribonucleoprotein particles (snRNPs) are required for pre-mRNA splicing throughout the nucleoplasm, yet snRNPs also concentrate in Cajal bodies (CBs). To address a proposed role of CBs in snRNP assembly, we have used fluorescence resonance energy transfer (FRET) microscopy ...