H.pylori感染对胃黏膜的损害,主要是H.pylori的病原因子一巳外及VacA起作用。CagA通过CagPAI的4型分泌结构而由Hpylori注入到胃黏膜上皮细胞,然后在上皮细胞内受酪氨酸磷酸化作用,并与细胞的增生及分化中起重要作用的SHP-2结合,从而含有CagPAI的H.pylori感染就会刺激人体上皮细胞内的信息传递系统而直接影响细胞的分化...
幽门螺杆菌与宿主博弈的“平衡点”—负调节因⼦CAPZA1抑制CagA⾃噬降解CagA(细胞毒素蛋⽩)是幽门螺杆菌(Helicobacter pylori,Hp)重要的毒⼒因⼦,在胃癌的 发⽣发展中起重要的作⽤。但是如果细胞内CagA确实触发了致癌途径,则它必须逃避⾃噬降 解。⽇本科学家Hidekazu Suzuki等⼈阐述了Hp感染的...
pylori infection and whether they can elaborate the risk of H. pylori-mediated inflammation and diseases, such as the strain type, the genetic background of the host which determines the state of immune response to the infection (in particular the proteins that regulate host inflammatory responses...
CagA+H.pylorirate in gastric cancer was higher than those in chronic gastric diseases (P<0.01). The positive rate of Bcl-2 expression in gastric cancer was higher than that in chronic gastric diseases (62%vs41%,P>0.05). In CagA+ gastric cancer it was higher than...
serum of anti-Hp IgE participated in H.pylori pathogenicity, but these were not correlation between the titre of serum anti-Hp IgE and anti-Hp CagA-IgG, which showed that anti-Hp IgE and anti-Hp Cag-IgG were independent pathogenic factor and multifactors were involved in H.pylori pathogens...
Helicobacter pylori infects about half of the world′s population. H. pylori elicits marked immune responses, but the infection is commonly life-long. Some... A Ibraghimov,J Pappo - 《Microbes & Infection》 被引量: 91发表: 2000年 Helicobacter pylori in gastroduodenal disease In the past de...
My accountSign inDigestive and Liver Disease Volume 41, Supplement 1, March 2009, Page S13Oral CommunicationsCAGA-POSITIVE STRAINS OF H. PYLORI CROSS REACT WITH TROPHOBLAST CELLS: A ROLE FOR PRE-ECLAMPSIA AND POLYABORTIVITY? Author links open overlay panelF. Franceschi, N. Di Simone, G. Gig...
幽门螺杆菌(H. pylori)是人类胃癌的I类致癌原. H. pylori分为cagA阳性菌株与cagA阴性菌株. 近年来的研究指出, cagA阳性菌株感染具有更强毒力和危险性. cagA阳性菌株与癌前病变及胃癌的关系更为密切. 从细胞动力学角度探讨H. pylori感染和胃癌的关系已成为研究的热点之一. H. pylori cagA感染与胃黏膜上皮细胞...
(the control group)from Jan.2014 to Nov.2016 in People's Hospital of Xinjiang Uygur Autonomous Region.The serum CagA and VacA antibody in H.pylori(Hp)were tested by Western blotting.The clinical characteristics such as age,gender,BMI,smoking history,alcohol history carcinoma history of the two...
activity. Interestingly, the suppression of GSK-3 by CagA also regulates protein abundance of another GSK-3 substrate, MCL-1, and active AMP-activated protein kinase (AMPK), indicating that GSK-3 depletion byH. pylorimay have a wider role in oncogenic pathways, beyond the Snail-mediated EMT ...